Il6 interleukin 6 [ Mus musculus (house mouse) ]

Gene ID: 16193, updated on 23-Dec-2024

Summary

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Official Symbol: Il6provided by MGI
Official Full Name: interleukin 6provided by MGI
Primary source: MGI:MGI:96559
See related: Ensembl:ENSMUSG00000025746 AllianceGenome:MGI:96559
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il-6
Summary: This gene encodes a member of the interleukin family of cytokines that have important functions in immune response, hematopoiesis, inflammation and the acute phase response. The ectopic overexpression of the encoded protein in mice results in excessive plasma cells in circulation, leading to death. Mice lacking the encoded protein exhibit abnormalities in hepatic acute phase response, some immune mechanisms, bone resorption in response to estrogen, liver regeneration and wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

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See Il6 in Genome Data Viewer

Location:: 5 B1; 5 15.7 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (30218112..30224973)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (30013114..30019975)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased Expression of the Neuropeptides PACAP/VIP in the Brain of Mice with CNS Targeted Production of IL-6 Is Mediated in Part by Trans-Signalling.
Title: Increased Expression of the Neuropeptides PACAP/VIP in the Brain of Mice with CNS Targeted Production of IL-6 Is Mediated in Part by Trans-Signalling.
Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation via the IL-6-STAT3 axis.
Title: Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation via the IL-6-STAT3 axis.
Acetylcholine receptor-beta inhibition by interleukin-6 in skeletal muscles contributes to modulating neuromuscular junction during aging.
Title: Acetylcholine receptor-β inhibition by interleukin-6 in skeletal muscles contributes to modulating neuromuscular junction during aging.
The NF-kappaB1/p50 Subunit Influences the Notch/IL-6-Driven Expansion of Myeloid-Derived Suppressor Cells in Murine T-Cell Acute Lymphoblastic Leukemia.
Title: The NF-κB1/p50 Subunit Influences the Notch/IL-6-Driven Expansion of Myeloid-Derived Suppressor Cells in Murine T-Cell Acute Lymphoblastic Leukemia.
Tumor-associated NK cells drive MDSC-mediated tumor immune tolerance through the IL-6/STAT3 axis.
Title: Tumor-associated NK cells drive MDSC-mediated tumor immune tolerance through the IL-6/STAT3 axis.
Absence of PD-L1 signaling hinders macrophage defense against Mycobacterium tuberculosis via upregulating STAT3/IL-6 pathway.
Title: Absence of PD-L1 signaling hinders macrophage defense against Mycobacterium tuberculosis via upregulating STAT3/IL-6 pathway.
Interleukin-6 and interferon-alpha differentially regulate microglia function.
Title: Interleukin-6 and interferon-alpha differentially regulate microglia function.
The increase of long noncoding RNA Fendrr in hepatocytes contributes to liver fibrosis by promoting IL-6 production.
Title: The increase of long noncoding RNA Fendrr in hepatocytes contributes to liver fibrosis by promoting IL-6 production.
Impact of Interleukin-6 Activation and Arthritis on Epidermal Growth Factor Receptor (EGFR) Activation in Sensory Neurons and the Spinal Cord.
Title: Impact of Interleukin-6 Activation and Arthritis on Epidermal Growth Factor Receptor (EGFR) Activation in Sensory Neurons and the Spinal Cord.
Histone demethylase JARID1C/KDM5C regulates Th17 cells by increasing IL-6 expression in diabetic plasmacytoid dendritic cells.
Title: Histone demethylase JARID1C/KDM5C regulates Th17 cells by increasing IL-6 expression in diabetic plasmacytoid dendritic cells.

Submit: New GeneRIF Correction See all GeneRIFs (1343)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (12) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Il6 (e-PCR), detects polymorphism
- UniSTS:257047

D5Mit44 (e-PCR), detects polymorphism
- UniSTS:130584

Il6 (e-PCR), detects polymorphism
- UniSTS:166224

PMC356028P2 (e-PCR)
- UniSTS:273264

J03783 (e-PCR)
- UniSTS:159349

D4Wox27 (e-PCR)
- UniSTS:239485

PMC209527P2 (e-PCR)
- UniSTS:272000

NoName (e-PCR)
- UniSTS:532119

Il6 (e-PCR), detects polymorphism
- UniSTS:532119

Il6 (e-PCR), detects polymorphism
- UniSTS:532128

NoName (e-PCR)
- UniSTS:532129

Il6 (e-PCR), detects polymorphism
- UniSTS:532129

Il6 (e-PCR), detects polymorphism
- UniSTS:143574

D5Mit410 (e-PCR), detects polymorphism
- UniSTS:142551

Il6 (e-PCR), detects polymorphism
- UniSTS:143575

Il6 (e-PCR), detects polymorphism
- UniSTS:143576

Il6 (e-PCR), detects polymorphism
- UniSTS:143577

Il6 (e-PCR), detects polymorphism
- UniSTS:143578

Il6 (e-PCR), detects polymorphism
- UniSTS:143579

D5Nds8 (e-PCR), detects polymorphism
- UniSTS:142563

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-6 receptor binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to interleukin-6 receptor binding	ISO Inferred from Sequence Orthology more info
enables interleukin-6 receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell activation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in T follicular helper cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T-helper 17 cell lineage commitment	IDA Inferred from Direct Assay more info	PubMed
involved_in T-helper 17 cell lineage commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T-helper 2 cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in acute-phase response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in salivary gland morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within branching involved in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell redox homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to hepatocyte growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to interleukin-1	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interleukin-17	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within cellular response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to protozoan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in endocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within_positive_effect gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in germinal center B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucagon secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in hepatic immune response	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response to wounding	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response to wounding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within interleukin-6-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-6-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-6-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in liver regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle cell cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within myeloid cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of chemokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of hormone secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-1-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of muscle organ development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of primary miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutrophil apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neutrophil apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 2 cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T-helper 2 cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic DNA fragmentation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell proliferation in bone marrow	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gliogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-17 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-21 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of leukocyte adhesion to vascular endothelial cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via STAT	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian sleep/wake cycle, non-REM sleep	ISO Inferred from Sequence Orthology more info
involved_in regulation of glucagon secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of glucagon secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IDA Inferred from Direct Assay more info	PubMed
involved_in response to glucocorticoid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to wounding	IDA Inferred from Direct Assay more info	PubMed
involved_in vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor production	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of interleukin-6 receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of interleukin-6 receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of interleukin-6 receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-6

Names: B-cell hybridoma growth factor; interleukin HP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001314054.1 → NP_001300983.1 interleukin-6 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon, compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC112933, AK150440, BC145409

Consensus CDS

CCDS84856.1

UniProtKB/TrEMBL

A0A0G2JGF4

Related

ENSMUSP00000143544.2, ENSMUST00000195978.5

Conserved Domains (1) summary

cl02473
Location:27 → 157

IL6; Interleukin-6/G-CSF/MGF family
NM_031168.2 → NP_112445.1 interleukin-6 isoform 1 precursor

See identical proteins and their annotated locations for NP_112445.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC112933, AK150440

Consensus CDS

CCDS19153.1

UniProtKB/Swiss-Prot

P08505, Q3UCQ0, Q8BN26

UniProtKB/TrEMBL

A2RTD1, Q0PMN1

Related

ENSMUSP00000026845.8, ENSMUST00000026845.12

Conserved Domains (1) summary

pfam00489
Location:27 → 210

IL6; Interleukin-6/G-CSF/MGF family