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    ELA1 elongin A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855491, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ELA1
    Official Full Name
    elongin A
    Primary source
    SGD:S000005174
    Locus tag
    YNL230C
    See related
    AllianceGenome:SGD:S000005174; FungiDB:YNL230C; VEuPathDB:YNL230C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to ubiquitin-protein transferase activity. Involved in ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Part of Cul3-RING ubiquitin ligase complex and elongin complex. Orthologous to several human genes including ELOA2 (elongin A2); ELOA3BP (elongin A3 family member B, pseudogene); and ELOA3CP (elongin A3 family member C, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ELA1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (217523..218662, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene exosome non-catalytic core subunit CSL4 Neighboring gene phosphatidylinositol transporter Neighboring gene glutathione peroxidase Neighboring gene Jjj1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Elongin from Saccharomyces cerevisiae. Koth CM, et al. J Biol Chem, 2000 Apr 14. PMID 10753924
    2. Binding of elongin A or a von Hippel-Lindau peptide stabilizes the structure of yeast elongin C. Botuyan MV, et al. Proc Natl Acad Sci U S A, 1999 Aug 3. PMID 10430890, Free PMC Article
    3. ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells. Ribar B, et al. Mol Cell Biol, 2007 Apr. PMID 17296727, Free PMC Article
    4. Distinct functions of the ubiquitin-proteasome pathway influence nucleotide excision repair. Gillette TG, et al. EMBO J, 2006 Jun 7. PMID 16675952, Free PMC Article
    5. Proteasome-mediated processing of Def1, a critical step in the cellular response to transcription stress. Wilson MD, et al. Cell, 2013 Aug 29. PMID 23993092, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    part_of elongin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of elongin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    elongin A
    NP_014169.1
    • Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      217523..218662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183068.1 → NP_014169.1  TPA: elongin A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014169.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0W2, P53861
      UniProtKB/TrEMBL
      A6ZRL2, B3LP71, C8ZG04, G2WLN5, N1NY23
      Conserved Domains (1) summary
      pfam06881
      Location:19 → 165
      Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53861.1

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