Cct6a chaperonin containing TCP1 subunit 6A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cct6aprovided by MGI
Official Full Name: chaperonin containing TCP1 subunit 6Aprovided by MGI
Primary source: MGI:MGI:107943
See related: Ensembl:ENSMUSG00000029447 AllianceGenome:MGI:107943
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cct6; Cctz-1; CCT-zeta; CCT-zeta-1; TCP-1-zeta
Summary: Predicted to enable WD40-repeat domain binding activity; protein folding chaperone; and unfolded protein binding activity. Acts upstream of or within binding activity of sperm to zona pellucida. Located in acrosomal vesicle and cell body. Part of chaperonin-containing T-complex and zona pellucida receptor complex. Is expressed in 8-cell stage embryo. Orthologous to human CCT6A (chaperonin containing TCP1 subunit 6A). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Note: This gene aligns across a gap in the GRCm38 reference genome assembly, and therefore, the 5' end of this gene was annotated on NT_039313.8 and the 3' end was annotated on NT_039314.8 in NCBI's Mus Musculus Annotation Release 105. [15 Jun 2015]
Expression: Broad expression in CNS E11.5 (RPKM 106.6), placenta adult (RPKM 82.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G1.3; 5 68.26 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (129864420..129875284)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (129787356..129846443)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

selective inhibition of SMAD3 or CCT6A efficiently suppresses TGF-beta-mediated metastasis. Findings provide a mechanism that directs TGF-beta signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta for non-small-cell lung carcinoma.
Title: CCT6A suppresses SMAD2 and promotes prometastatic TGF-β signaling.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Z31557 (e-PCR)
- UniSTS:159449

Cct6a (e-PCR), detects polymorphism
- UniSTS:536564

Cct6a (e-PCR), detects polymorphism
- UniSTS:536565

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables WD40-repeat domain binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein folding chaperone	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within binding of sperm to zona pellucida	IDA Inferred from Direct Assay more info	PubMed
involved_in chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of establishment of protein localization to telomere	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein folding	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
part_of chaperonin-containing T-complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chaperonin-containing T-complex	IDA Inferred from Direct Assay more info	PubMed
part_of chaperonin-containing T-complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
part_of zona pellucida receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: T-complex protein 1 subunit zeta

Names: chaperonin containing TCP-1; chaperonin containing Tcp1, subunit 6a (zeta); chaperonin subunit 6a (zeta)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009838.3 → NP_033968.2 T-complex protein 1 subunit zeta

Status: VALIDATED

Source sequence(s)

MG954262

UniProtKB/TrEMBL

Q3TIX8, Q3TW97, Q52KG9

Related

ENSMUSP00000159385.2, ENSMUST00000201414.5

Conserved Domains (1) summary

TIGR02347
Location:3 → 530

chap_CCT_zeta; T-complex protein 1, zeta subunit