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    Septin4 septin 4 [ Mus musculus (house mouse) ]

    Gene ID: 18952, updated on 9-Dec-2024

    Summary

    Official Symbol
    Septin4provided by MGI
    Official Full Name
    septin 4provided by MGI
    Primary source
    MGI:MGI:1270156
    See related
    Ensembl:ENSMUSG00000020486 AllianceGenome:MGI:1270156
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bh5; ARTS; Sept4; Pnutl2; Gm11492; hCDCREL-2
    Summary
    Predicted to enable several functions, including GTP binding activity; GTPase activity; and magnesium ion binding activity. Involved in several processes, including flagellated sperm motility; hematopoietic stem cell homeostasis; and negative regulation of stem cell proliferation. Acts upstream of or within brain development; sperm capacitation; and sperm mitochondrion organization. Located in several cellular components, including axon terminus; perikaryon; and sperm annulus. Part of septin complex. Is expressed in several structures, including central nervous system; sensory organ; and testis. Orthologous to human SEPTIN4 (septin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 67.1), testis adult (RPKM 31.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Septin4 in Genome Data Viewer
    Location:
    11 C; 11 52.14 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87457515..87481365)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87566689..87590543)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene testis expressed gene 14 intercellular bridge forming factor Neighboring gene STARR-seq mESC enhancer starr_30291 Neighboring gene small nucleolar RNA, C/D box 3B2 Neighboring gene STARR-seq mESC enhancer starr_30292 Neighboring gene predicted gene, 34000 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87405102-87405211 Neighboring gene STARR-positive B cell enhancer ABC_E68 Neighboring gene STARR-seq mESC enhancer starr_30293 Neighboring gene myotubularin related protein 4 Neighboring gene heat shock transcription factor family member 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within sperm capacitation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sperm mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatid differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dopaminergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in motile cilium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in myelin sheath HDA PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of septin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of septin complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in sperm annulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sperm annulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm annulus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    septin-4
    Names
    CE5B3 beta
    M-Septin
    bradeion beta
    brain protein H5
    cell division control-related protein 2
    cell division control-related protein 2b
    peanut-like 2 homolog
    peanut-like protein 2
    septin H5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284392.2NP_001271321.1  septin-4 isoform 2

      See identical proteins and their annotated locations for NP_001271321.1

      Status: VALIDATED

      Source sequence(s)
      AL596086
      Consensus CDS
      CCDS70277.1
      UniProtKB/Swiss-Prot
      P28661
      Related
      ENSMUSP00000060127.5, ENSMUST00000063156.11
      Conserved Domains (2) summary
      COG5019
      Location:25377
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:42315
      Septin; Septin
    2. NM_001284394.2NP_001271323.1  septin-4 isoform 3

      See identical proteins and their annotated locations for NP_001271323.1

      Status: VALIDATED

      Source sequence(s)
      AL596086
      Consensus CDS
      CCDS70276.1
      UniProtKB/Swiss-Prot
      P28661
      Related
      ENSMUSP00000103594.2, ENSMUST00000107960.8
      Conserved Domains (1) summary
      pfam00735
      Location:141421
      Septin
    3. NM_001284398.2NP_001271327.1  septin-4 isoform 4

      See identical proteins and their annotated locations for NP_001271327.1

      Status: VALIDATED

      Source sequence(s)
      AL596086
      Consensus CDS
      CCDS70275.1
      UniProtKB/Swiss-Prot
      P28661
      Related
      ENSMUSP00000112960.2, ENSMUST00000122067.8
      Conserved Domains (1) summary
      pfam00735
      Location:24296
      Septin
    4. NM_001361936.2NP_001348865.1  septin-4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL596086
      Consensus CDS
      CCDS88214.1
      Related
      ENSMUSP00000103596.2, ENSMUST00000107962.8
      Conserved Domains (1) summary
      pfam00735
      Location:122402
      Septin
    5. NM_001368775.2NP_001355704.1  septin-4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL596086
      Conserved Domains (2) summary
      pfam00735
      Location:635907
      Septin
      pfam15548
      Location:14509
      DUF4655; Domain of unknown function (DUF4655)
    6. NM_001368776.2NP_001355705.1  septin-4 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL596086
      Conserved Domains (1) summary
      pfam00735
      Location:135407
      Septin
    7. NM_001368777.2NP_001355706.1  septin-4 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL596086
      Related
      ENSMUST00000133638.8
      Conserved Domains (1) summary
      pfam00735
      Location:24296
      Septin
    8. NM_001368778.2NP_001355707.1  septin-4 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL596086
      Conserved Domains (1) summary
      pfam00735
      Location:122402
      Septin
    9. NM_001368779.2NP_001355708.1  septin-4 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL596086
      Conserved Domains (1) summary
      pfam00735
      Location:135407
      Septin
    10. NM_001424196.1NP_001411125.1  septin-4 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL596086
      UniProtKB/TrEMBL
      A0A5F8MP96
      Related
      ENSMUSP00000158869.2, ENSMUST00000239011.2
    11. NM_011129.3NP_035259.1  septin-4 isoform 1

      See identical proteins and their annotated locations for NP_035259.1

      Status: VALIDATED

      Source sequence(s)
      AL596086
      Consensus CDS
      CCDS25213.1
      UniProtKB/Swiss-Prot
      B2KGM3, B2KGM6, P28661, Q3UVH1, Q3UZC3, Q5ND10, Q5ND15, Q5ND16, Q5ND19, Q7TPM7, Q80VX1
      Related
      ENSMUSP00000018544.6, ENSMUST00000018544.12
      Conserved Domains (1) summary
      pfam00735
      Location:141421
      Septin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      87457515..87481365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245663.2XP_030101523.1  septin-4 isoform X2

      Conserved Domains (2) summary
      pfam15548
      Location:14509
      DUF4655; Domain of unknown function (DUF4655)
      cl38985
      Location:634759
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_030245665.2XP_030101525.1  septin-4 isoform X6

      Conserved Domains (1) summary
      pfam00735
      Location:35315
      Septin
    3. XM_036156427.1XP_036012320.1  septin-4 isoform X10

      Conserved Domains (1) summary
      pfam00735
      Location:1232
      Septin
    4. XM_036156428.1XP_036012321.1  septin-4 isoform X10

      Conserved Domains (1) summary
      pfam00735
      Location:1232
      Septin
    5. XM_036156425.1XP_036012318.1  septin-4 isoform X3

      Conserved Domains (1) summary
      pfam00735
      Location:134406
      Septin
    6. XM_036156426.1XP_036012319.1  septin-4 isoform X7

      Conserved Domains (1) summary
      pfam00735
      Location:35307
      Septin
    7. XM_030245666.2XP_030101526.1  septin-4 isoform X8

      Conserved Domains (1) summary
      pfam00735
      Location:43315
      Septin
    8. XM_030245664.2XP_030101524.1  septin-4 isoform X5

      Conserved Domains (1) summary
      pfam00735
      Location:131411
      Septin
    9. XM_006532497.4XP_006532560.1  septin-4 isoform X4

      See identical proteins and their annotated locations for XP_006532560.1

      Conserved Domains (1) summary
      pfam00735
      Location:131411
      Septin
    10. XM_030245667.1XP_030101527.1  septin-4 isoform X9

      Conserved Domains (1) summary
      pfam00735
      Location:1267
      Septin

    RNA

    1. XR_004936842.1 RNA Sequence

    2. XR_004936843.1 RNA Sequence

    3. XR_004936844.1 RNA Sequence

    4. XR_388364.3 RNA Sequence

    5. XR_001779919.3 RNA Sequence