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    Ska2 spindle and kinetochore associated complex subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 66140, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ska2provided by MGI
    Official Full Name
    spindle and kinetochore associated complex subunit 2provided by MGI
    Primary source
    MGI:MGI:1913390
    See related
    Ensembl:ENSMUSG00000020492 AllianceGenome:MGI:1913390
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam33a; 1110001A07Rik
    Summary
    Predicted to enable microtubule binding activity. Involved in establishment of meiotic spindle orientation and spindle assembly involved in female meiosis. Located in meiotic spindle. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and respiratory system. Orthologous to human SKA2 (spindle and kinetochore associated complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 49.3), limb E14.5 (RPKM 25.9) and 14 other tissues See more
    Orthologs
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    Genomic context

    See Ska2 in Genome Data Viewer
    Location:
    11 C; 11 51.91 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87000087..87013800)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87109261..87122974)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E26 Neighboring gene SMG8 nonsense mediated mRNA decay factor Neighboring gene proline rich 11 Neighboring gene microRNA 301 Neighboring gene tripartite motif-containing 37 Neighboring gene STARR-seq mESC enhancer starr_30287 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87059058-87059211 Neighboring gene protein phosphatase 1E (PP2C domain containing) Neighboring gene predicted gene, 33937 Neighboring gene predicted gene, 22883

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC151378

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in attachment of mitotic spindle microtubules to kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of meiotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic metaphase chromosome alignment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic sister chromatid segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of microtubule polymerization or depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of microtubule polymerization or depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spindle assembly involved in female meiosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SKA complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in meiotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of outer kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of outer kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    part_of outer kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    SKA complex subunit 2
    Names
    family with sequence similarity 33, member A
    spindle and kinetochore-associated protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025377.3NP_079653.1  SKA complex subunit 2

      See identical proteins and their annotated locations for NP_079653.1

      Status: PROVISIONAL

      Source sequence(s)
      AL713917
      Consensus CDS
      CCDS25209.1
      UniProtKB/Swiss-Prot
      B2KGY1, Q9CR46
      Related
      ENSMUSP00000020794.6, ENSMUST00000020794.6
      Conserved Domains (1) summary
      cl17165
      Location:5120
      SKA2; Spindle and kinetochore-associated protein 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      87000087..87013800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)