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    Smg8 SMG8 nonsense mediated mRNA decay factor [ Mus musculus (house mouse) ]

    Gene ID: 74133, updated on 9-Dec-2024

    Summary

    Official Symbol
    Smg8provided by MGI
    Official Full Name
    SMG8 nonsense mediated mRNA decay factorprovided by MGI
    Primary source
    MGI:MGI:1921383
    See related
    Ensembl:ENSMUSG00000020495 AllianceGenome:MGI:1921383
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200011M11Rik
    Summary
    Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and regulation of protein kinase activity. Orthologous to human SMG8 (SMG8 nonsense mediated mRNA decay factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.0), limb E14.5 (RPKM 6.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Smg8 in Genome Data Viewer
    Location:
    11 C; 11 51.89 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (86968558..86977603, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87077732..87086777, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22387 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 1 Neighboring gene proline rich 11 Neighboring gene STARR-positive B cell enhancer ABC_E26 Neighboring gene spindle and kinetochore associated complex subunit 2 Neighboring gene microRNA 301

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    nonsense-mediated mRNA decay factor SMG8
    Names
    CG6729 gene product
    protein SMG8
    protein smg-8 homolog
    smg-8 homolog, nonsense mediated mRNA decay factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024262.1NP_077224.1  nonsense-mediated mRNA decay factor SMG8

      See identical proteins and their annotated locations for NP_077224.1

      Status: PROVISIONAL

      Source sequence(s)
      BC020005
      Consensus CDS
      CCDS25207.1
      UniProtKB/Swiss-Prot
      B2KGQ4, Q8BS62, Q8BSP7, Q8VE18, Q9DBW6
      Related
      ENSMUSP00000020801.8, ENSMUST00000020801.14
      Conserved Domains (1) summary
      pfam10220
      Location:42985
      Smg8_Smg9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      86968558..86977603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)