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    ATG41 Atg41p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855825, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ATG41
    Official Full Name
    Atg41p
    Primary source
    SGD:S000006171
    Locus tag
    YPL250C
    See related
    AllianceGenome:SGD:S000006171; FungiDB:YPL250C; VEuPathDB:YPL250C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ICY2
    Summary
    Involved in several processes, including autophagosome assembly; cellular response to nitrogen starvation; and cytoplasm to vacuole targeting by the Cvt pathway. Predicted to be located in phagophore assembly site membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ATG41 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (74309..74719, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Vik1p Neighboring gene adrenodoxin Neighboring gene ribosomal 60S subunit protein L36B Neighboring gene GTPase-activating protein GYP5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide analysis of mRNA translation profiles in Saccharomyces cerevisiae. Arava Y, et al. Proc Natl Acad Sci U S A, 2003 Apr 1. PMID 12660367, Free PMC Article
    2. Lawsone, a 2-hydroxy-1,4-naphthoquinone from Lawsonia inermis (henna), produces mitochondrial dysfunctions and triggers mitophagy in Saccharomyces cerevisiae. Xavier MR, et al. Mol Biol Rep, 2020 Feb. PMID 31811499
    3. Global and specific translational regulation in the genomic response of Saccharomyces cerevisiae to a rapid transfer from a fermentable to a nonfermentable carbon source. Kuhn KM, et al. Mol Cell Biol, 2001 Feb. PMID 11154278, Free PMC Article
    4. Atg41/Icy2 regulates autophagosome formation. Yao Z, et al. Autophagy, 2015. PMID 26565778, Free PMC Article
    5. An Autophagy-Independent Role for ATG41 in Sulfur Metabolism During Zinc Deficiency. Bucci MD, et al. Genetics, 2018 Mar. PMID 29321173, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to nitrogen starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagophore assembly site membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Atg41p
    NP_015073.1
    • hypothetical protein; required for selective and nonselective autophagy, and mitophagy; regulates the rate of autophagosome formation; interacts with Atg9p, and has a similar peri-mitochondrial localization; elevated Gcn4p-dependent expression under autophagy-inducing conditions; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate; ATG41 has a paralog, ICY1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      74309..74719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184064.1 → NP_015073.1  TPA: Atg41p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015073.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3C0, Q12048
      UniProtKB/TrEMBL
      B3LKI1, C7GTQ8, C8ZIC8, G2WNT4, N1NW53
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12048.1

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