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    Ciao2a cytosolic iron-sulfur assembly component 2A [ Mus musculus (house mouse) ]

    Gene ID: 68250, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ciao2aprovided by MGI
    Official Full Name
    cytosolic iron-sulfur assembly component 2Aprovided by MGI
    Primary source
    MGI:MGI:1915500
    See related
    Ensembl:ENSMUSG00000032381 AllianceGenome:MGI:1915500
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam96a; 5730536A07Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of cytosolic [4Fe-4S] assembly targeting complex. Is expressed in liver. Orthologous to human CIAO2A (cytosolic iron-sulfur assembly component 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 28.8), liver E14.5 (RPKM 23.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ciao2a in Genome Data Viewer
    Location:
    9 C; 9 35.73 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (66033878..66046250)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (66126596..66138968)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6757 Neighboring gene STARR-positive B cell enhancer ABC_E11412 Neighboring gene peptidylprolyl isomerase B Neighboring gene sorting nexin 22 Neighboring gene STARR-seq mESC enhancer starr_24475 Neighboring gene sorting nexin 1 Neighboring gene STARR-positive B cell enhancer ABC_E5080 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:65974328-65974632 Neighboring gene death-associated protein kinase 2 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66059936-66060237 Neighboring gene ribosomal protein S27 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in iron-sulfur cluster assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in iron-sulfur cluster assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein maturation by [4Fe-4S] cluster transfer IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein maturation by iron-sulfur cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein maturation by iron-sulfur cluster transfer ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein maturation by iron-sulfur cluster transfer ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytosolic [4Fe-4S] assembly targeting complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytosolic [4Fe-4S] assembly targeting complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cytosolic iron-sulfur assembly component 2A
    Names
    MIP18 family protein FAM96A
    family with sequence similarity 96, member A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359210.1NP_001346139.1  cytosolic iron-sulfur assembly component 2A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC112676, AC124439
      Conserved Domains (1) summary
      cl00941
      Location:3996
      DUF59; Domain of unknown function DUF59
    2. NM_026635.3NP_080911.1  cytosolic iron-sulfur assembly component 2A isoform 1

      See identical proteins and their annotated locations for NP_080911.1

      Status: VALIDATED

      Source sequence(s)
      AK077700, BE655498
      Consensus CDS
      CCDS23302.1
      UniProtKB/Swiss-Prot
      Q3TD02, Q9D171, Q9DCL2
      Related
      ENSMUSP00000034945.6, ENSMUST00000034945.6
      Conserved Domains (1) summary
      cl00941
      Location:39156
      FeS_assembly_P; Iron-sulfur cluster assembly protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      66033878..66046250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242805.2XP_011241107.1  cytosolic iron-sulfur assembly component 2A isoform X2

      Conserved Domains (1) summary
      cl00941
      Location:39124
      FeS_assembly_P; Iron-sulfur cluster assembly protein
    2. XM_036155224.1XP_036011117.1  cytosolic iron-sulfur assembly component 2A isoform X1

      Conserved Domains (1) summary
      cl00941
      Location:81142
      FeS_assembly_P; Iron-sulfur cluster assembly protein