Mief1 mitochondrial elongation factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mief1provided by MGI
Official Full Name: mitochondrial elongation factor 1provided by MGI
Primary source: MGI:MGI:2146020
See related: Ensembl:ENSMUSG00000022412 AllianceGenome:MGI:2146020
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Smcr7l; A230016E22
Summary: Enables identical protein binding activity. Involved in positive regulation of mitochondrial fission. Located in mitochondrion. Human ortholog(s) of this gene implicated in optic atrophy. Orthologous to human MIEF1 (mitochondrial elongation factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 13.4), thymus adult (RPKM 8.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.85 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (80118284..80137572)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (80233964..80253372)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiD51 can suppress Mff-dependent enhancement of Drp1 GTPase activity.
Title: Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission.
This paper combines confocal live-cell imaging with correlative cryogenic fluorescence microscopy and soft x-ray tomography to link MiD49 and MiD51 to the involvement of the endoplasmic reticulum in mitochondrial fission.
Title: Analysis of ER-mitochondria contacts using correlative fluorescence microscopy and soft X-ray tomography of mammalian cells.
ADP is an essential cofactor for MiD51 during mitochondrial fission.
Title: The mitochondrial fission receptor MiD51 requires ADP as a cofactor.
MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and suggest that they provide specificity to the division of mitochondria.
Title: Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D15Mit261 (e-PCR), detects polymorphism
- UniSTS:127634

AI452372 (e-PCR)
- UniSTS:160469

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to membrane	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial dynamics protein MID51

Names: Smith-Magenis syndrome chromosome region, candidate 7-like; mitochondrial dynamic protein MID51; mitochondrial dynamic protein of 51 kDa homolog; mitochondrial dynamics protein of 51 kDa homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357659.2 → NP_001344588.1 mitochondrial dynamics protein MID51 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AC140267

Consensus CDS

CCDS27661.1

UniProtKB/Swiss-Prot

Q8BGV8, Q8C4Y9

UniProtKB/TrEMBL

B2RPW2

Related

ENSMUSP00000154875.2, ENSMUST00000229138.2

Conserved Domains (1) summary

pfam03281
Location:191 → 446

Mab-21; Mab-21 protein
NM_001357660.2 → NP_001344589.1 mitochondrial dynamics protein MID51 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC140267

Conserved Domains (1) summary

pfam03281
Location:13 → 268

Mab-21; Mab-21 protein
NM_001416091.1 → NP_001403020.1 mitochondrial dynamics protein MID51 isoform 1

Status: VALIDATED

Source sequence(s)

AC140267

UniProtKB/Swiss-Prot

Q8BGV8, Q8C4Y9

UniProtKB/TrEMBL

B2RPW2
NM_001416092.1 → NP_001403021.1 mitochondrial dynamics protein MID51 isoform 1

Status: VALIDATED

Source sequence(s)

AC140267

UniProtKB/Swiss-Prot

Q8BGV8, Q8C4Y9

UniProtKB/TrEMBL

B2RPW2
NM_001416093.1 → NP_001403022.1 mitochondrial dynamics protein MID51 isoform 1

Status: VALIDATED

Source sequence(s)

AC140267

UniProtKB/Swiss-Prot

Q8BGV8, Q8C4Y9

UniProtKB/TrEMBL

B2RPW2
NM_001416094.1 → NP_001403023.1 mitochondrial dynamics protein MID51 isoform 1

Status: VALIDATED

Source sequence(s)

AC140267

UniProtKB/Swiss-Prot

Q8BGV8, Q8C4Y9

UniProtKB/TrEMBL

B2RPW2
NM_001416095.1 → NP_001403024.1 mitochondrial dynamics protein MID51 isoform 2

Status: VALIDATED

Source sequence(s)

AC140267
NM_001416096.1 → NP_001403025.1 mitochondrial dynamics protein MID51 isoform 2

Status: VALIDATED

Source sequence(s)

AC140267
NM_001416097.1 → NP_001403026.1 mitochondrial dynamics protein MID51 isoform 2

Status: VALIDATED

Source sequence(s)

AC140267
NM_178719.6 → NP_848834.2 mitochondrial dynamics protein MID51 isoform 1

See identical proteins and their annotated locations for NP_848834.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC140267

Consensus CDS

CCDS27661.1

UniProtKB/Swiss-Prot

Q8BGV8, Q8C4Y9

UniProtKB/TrEMBL

B2RPW2

Related

ENSMUSP00000023048.5, ENSMUST00000023048.12

Conserved Domains (1) summary

pfam03281
Location:191 → 446

Mab-21; Mab-21 protein