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    Amacr alpha-methylacyl-CoA racemase [ Mus musculus (house mouse) ]

    Gene ID: 17117, updated on 9-Dec-2024

    Summary

    Official Symbol
    Amacrprovided by MGI
    Official Full Name
    alpha-methylacyl-CoA racemaseprovided by MGI
    Primary source
    MGI:MGI:1098273
    See related
    Ensembl:ENSMUSG00000022244 AllianceGenome:MGI:1098273
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Macr1
    Summary
    Predicted to enable alpha-methylacyl-CoA racemase activity and signaling receptor binding activity. Predicted to be involved in bile acid biosynthetic process. Predicted to act upstream of or within isoprenoid catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; cranium; genitourinary system; liver; and respiratory system. Used to study alpha-methylacyl-CoA racemase deficiency. Human ortholog(s) of this gene implicated in alpha-methylacyl-CoA racemase deficiency; congenital bile acid synthesis defect 4; and urinary bladder cancer. Orthologous to human AMACR (alpha-methylacyl-CoA racemase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver adult (RPKM 25.9), kidney adult (RPKM 22.2) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Amacr in Genome Data Viewer
    Location:
    15 A1; 15 5.39 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (10981875..10995693)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (10981756..10996624)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29742 Neighboring gene predicted gene, 34315 Neighboring gene C1q and tumor necrosis factor related protein 3 Neighboring gene STARR-seq mESC enhancer starr_37987 Neighboring gene predicted gene, 52174 Neighboring gene solute carrier family 45, member 2 Neighboring gene STARR-seq mESC enhancer starr_37988 Neighboring gene relaxin family peptide receptor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-methylacyl-CoA racemase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables alpha-methylacyl-CoA racemase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables alpha-methylacyl-CoA racemase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables alpha-methylacyl-CoA racemase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in bile acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bile acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in bile acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within isoprenoid catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    alpha-methylacyl-CoA racemase
    Names
    2-arylpropionyl-CoA epimerase
    2-methylacyl-CoA racemase
    alpha-methylacyl-Coenzyme A racemase
    NP_032563.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008537.5NP_032563.2  alpha-methylacyl-CoA racemase

      Status: VALIDATED

      Source sequence(s)
      AC102219
      Consensus CDS
      CCDS27381.1
      UniProtKB/Swiss-Prot
      O09174, Q543Q9, Q9DCW6
      UniProtKB/TrEMBL
      Q3TUS8
      Related
      ENSMUSP00000066915.6, ENSMUST00000070877.7
      Conserved Domains (1) summary
      COG1804
      Location:3372
      CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

    RNA

    1. NR_177236.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC102219

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      10981875..10995693
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)