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    Defb11 defensin beta 11 [ Mus musculus (house mouse) ]

    Gene ID: 246081, updated on 27-Nov-2024

    Summary

    Official Symbol
    Defb11provided by MGI
    Official Full Name
    defensin beta 11provided by MGI
    Primary source
    MGI:MGI:2179197
    See related
    Ensembl:ENSMUSG00000045337 AllianceGenome:MGI:2179197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BD-11; Defb8
    Summary
    Predicted to enable CCR6 chemokine receptor binding activity. Predicted to be involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and innate immune response in mucosa. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in central nervous system and retina. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 48.6), testis adult (RPKM 9.6) and 1 other tissue See more
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    Genomic context

    See Defb11 in Genome Data Viewer
    Location:
    8 A2; 8 10.59 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22395383..22396448, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (21905374..21906432, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene defensin beta 10 Neighboring gene defensin beta 9 Neighboring gene predicted gene, 36879 Neighboring gene defensin beta 15 Neighboring gene defensin beta 35

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR6 chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response in mucosa IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139221.3NP_631967.1  beta-defensin 11 precursor

      See identical proteins and their annotated locations for NP_631967.1

      Status: VALIDATED

      Source sequence(s)
      AL590619
      Consensus CDS
      CCDS52515.1
      UniProtKB/Swiss-Prot
      Q499L3, Q8R2I7
      Related
      ENSMUSP00000053932.5, ENSMUST00000051965.5
      Conserved Domains (1) summary
      pfam00711
      Location:3667
      Defensin_beta; Beta defensin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      22395383..22396448 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)