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    Ppm1e protein phosphatase 1E (PP2C domain containing) [ Mus musculus (house mouse) ]

    Gene ID: 320472, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ppm1eprovided by MGI
    Official Full Name
    protein phosphatase 1E (PP2C domain containing)provided by MGI
    Primary source
    MGI:MGI:2444096
    See related
    Ensembl:ENSMUSG00000046442 AllianceGenome:MGI:2444096
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    POPX1; PP2CH; mKIAA1072; B930008A12Rik
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Involved in protein dephosphorylation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including adipose tissue; bone; central nervous system; retina; and spleen. Orthologous to human PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 37.0), CNS E18 (RPKM 18.9) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Ppm1e in Genome Data Viewer
    Location:
    11 C; 11 51.99 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87117724..87249884, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87226906..87358994, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E26 Neighboring gene proline rich 11 Neighboring gene microRNA 301 Neighboring gene spindle and kinetochore associated complex subunit 2 Neighboring gene STARR-seq mESC enhancer starr_30287 Neighboring gene tripartite motif-containing 37 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87059058-87059211 Neighboring gene predicted gene, 33937 Neighboring gene predicted gene, 22883 Neighboring gene STARR-positive B cell enhancer ABC_E3005 Neighboring gene RAD51 paralog C Neighboring gene VISTA enhancer mm264 Neighboring gene testis expressed gene 14 intercellular bridge forming factor Neighboring gene U1a1 small nuclear RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-threonine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein phosphatase 1E
    Names
    ca(2+)/calmodulin-dependent protein kinase phosphatase N
    caMKN
    caMKP-N
    caMKP-nucleus
    partner of PIX 1
    partner of PIX-alpha
    partner of PIXA
    NP_796141.2
    XP_036012659.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177167.4NP_796141.2  protein phosphatase 1E

      Status: VALIDATED

      Source sequence(s)
      AL596130
      Consensus CDS
      CCDS25211.1
      UniProtKB/Swiss-Prot
      Q5SX30, Q80TL0, Q8BGM6, Q8CB81
      UniProtKB/TrEMBL
      B2KGP3
      Related
      ENSMUSP00000061278.5, ENSMUST00000055438.5
      Conserved Domains (1) summary
      cd00143
      Location:227485
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      87117724..87249884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156766.1XP_036012659.1  protein phosphatase 1E isoform X1

      Conserved Domains (1) summary
      cd00143
      Location:233422
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...