Cela3b chymotrypsin-like elastase family, member 3B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cela3bprovided by MGI
Official Full Name: chymotrypsin-like elastase family, member 3Bprovided by MGI
Primary source: MGI:MGI:1915118
See related: Ensembl:ENSMUSG00000023433 AllianceGenome:MGI:1915118
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ela3; Ela3b; 0910001F22Rik; 2310074F01Rik
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Located in collagen-containing extracellular matrix. Is expressed in pancreas and pancreas tip epithelium. Orthologous to several human genes including CELA3B (chymotrypsin like elastase 3B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in small intestine adult (RPKM 4481.6), spleen adult (RPKM 2540.8) and 2 other tissues See more
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Genomic context

Location:: 4 D3; 4 69.9 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (137148319..137157831, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (137421008..137430520, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: chymotrypsin-like elastase family member 3B

Names: elastase 3, pancreatic; elastase 3B, pancreatic; elastase IIIB; elastase-3B; protease E

NP_080695.1

EC 3.4.21.70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026419.2 → NP_080695.1 chymotrypsin-like elastase family member 3B precursor

See identical proteins and their annotated locations for NP_080695.1

Status: PROVISIONAL

Source sequence(s)

AL645468

Consensus CDS

CCDS18817.1

UniProtKB/Swiss-Prot

Q7TNI0, Q9CQ52, Q9D7T9

Related

ENSMUSP00000099581.5, ENSMUST00000102522.5

Conserved Domains (2) summary

smart00020
Location:27 → 262

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:28 → 265

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...