Rxfp4 relaxin family peptide receptor 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rxfp4provided by MGI
Official Full Name: relaxin family peptide receptor 4provided by MGI
Primary source: MGI:MGI:2182926
See related: Ensembl:ENSMUSG00000049741 AllianceGenome:MGI:2182926
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SALPR; Gpr100; Rln3r2; GPCR142
Summary: Predicted to enable G protein-coupled peptide receptor activity. Acts upstream of or within positive regulation of feeding behavior. Predicted to be active in plasma membrane. Is expressed in alimentary system; genitourinary system; respiratory system; and thymus. Orthologous to human RXFP4 (relaxin family peptide/INSL5 receptor 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 38.92 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (88559081..88560489, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (88651898..88653142, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Evidence that RXFP4 is located in enterochromaffin cells and can regulate production and release of serotonin.
Title: Evidence that RXFP4 is located in enterochromaffin cells and can regulate production and release of serotonin.
Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice.
Title: Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice.
Colokinetic effect of an insulin-like peptide 5-related agonist of the RXFP4 receptor.
Title: Colokinetic effect of an insulin-like peptide 5-related agonist of the RXFP4 receptor.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of feeding behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: relaxin-3 receptor 2

Names: G protein-coupled receptor 100; RLN3 receptor 2; insulin-like peptide INSL5 receptor; relaxin-3/INSL7 receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.