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    Npr3 natriuretic peptide receptor 3 [ Mus musculus (house mouse) ]

    Gene ID: 18162, updated on 9-Dec-2024

    Summary

    Official Symbol
    Npr3provided by MGI
    Official Full Name
    natriuretic peptide receptor 3provided by MGI
    Primary source
    MGI:MGI:97373
    See related
    Ensembl:ENSMUSG00000022206 AllianceGenome:MGI:97373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    lgj; EF-2; stri; ANP-C; NPR-C; ANPR-C
    Summary
    Predicted to enable several functions, including chloride ion binding activity; peptide receptor activity; and protein homodimerization activity. Involved in several processes, including negative regulation of cold-induced thermogenesis; osteoclast proliferation; and response to ischemia. Predicted to be located in plasma membrane. Predicted to be part of protein-containing complex. Is expressed in several structures, including central nervous system; gut; heart and pericardium; lung; and urinary system. Used to study bone disease. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPR3 (natriuretic peptide receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 24.7), subcutaneous fat pad adult (RPKM 23.3) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Npr3 in Genome Data Viewer
    Location:
    15 A1; 15 5.83 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (11839982..11907287, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (11839896..11907837, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37999 Neighboring gene predicted gene, 41272 Neighboring gene predicted gene, 34501 Neighboring gene STARR-seq mESC enhancer starr_38001 Neighboring gene STARR-seq mESC enhancer starr_38002 Neighboring gene predicted gene 5144 Neighboring gene RIKEN cDNA 1700047G03 gene Neighboring gene predicted gene, 34618 Neighboring gene SEC13 homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chloride ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chloride ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables natriuretic peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables natriuretic peptide receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables natriuretic peptide receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables peptide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide hormone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in osteoclast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of pancreatic juice secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of urine volume IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of osteoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to ischemia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in skeletal system development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    atrial natriuretic peptide receptor 3
    Names
    Nppc receptor
    atrial natriuretic peptide clearance receptor
    atrial natriuretic peptide receptor type C
    longjohn
    strigosus

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039181.2NP_001034270.1  atrial natriuretic peptide receptor 3 isoform b precursor

      See identical proteins and their annotated locations for NP_001034270.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to variant a.
      Source sequence(s)
      AC134793
      Consensus CDS
      CCDS88736.1
      UniProtKB/TrEMBL
      Q7TMG7
      Related
      ENSMUSP00000154180.2, ENSMUST00000228603.2
      Conserved Domains (3) summary
      cd06386
      Location:49440
      PBP1_NPR_C_like; Ligand-binding domain of type C natriuretic peptide receptor
      cd12841
      Location:466501
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
      pfam01094
      Location:66419
      ANF_receptor; Receptor family ligand binding region
    2. NM_001286395.2NP_001273324.1  atrial natriuretic peptide receptor 3 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks part of the 5' coding region, uses an alternate in-frame splice site in the 3' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
      Source sequence(s)
      AC134793
      Consensus CDS
      CCDS88735.1
      UniProtKB/TrEMBL
      A0A2I3BPR9
      Related
      ENSMUSP00000153895.2, ENSMUST00000228489.2
      Conserved Domains (2) summary
      cl10011
      Location:1187
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
      cl25995
      Location:212247
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
    3. NM_001411434.1NP_001398363.1  atrial natriuretic peptide receptor 3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC134793
      UniProtKB/TrEMBL
      A0A2I3BPR9
    4. NM_001411435.1NP_001398364.1  atrial natriuretic peptide receptor 3 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC134793
    5. NM_001411436.1NP_001398365.1  atrial natriuretic peptide receptor 3 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC134793
    6. NM_008728.3NP_032754.2  atrial natriuretic peptide receptor 3 isoform a precursor

      See identical proteins and their annotated locations for NP_032754.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC134793
      Consensus CDS
      CCDS27386.1
      UniProtKB/Swiss-Prot
      G3X9E5, P70180, P97804, Q9R025, Q9R027, Q9R028
      Related
      ENSMUSP00000066737.4, ENSMUST00000066529.5
      Conserved Domains (3) summary
      cd06386
      Location:49440
      PBP1_NPR_C_like; Ligand-binding domain of type C natriuretic peptide receptor
      cd12841
      Location:471502
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
      pfam01094
      Location:66419
      ANF_receptor; Receptor family ligand binding region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      11839982..11907287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248376.1XP_030104236.1  atrial natriuretic peptide receptor 3 isoform X1

      Conserved Domains (2) summary
      cl10011
      Location:1187
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
      cl25995
      Location:217248
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
    2. XM_006520031.4XP_006520094.1  atrial natriuretic peptide receptor 3 isoform X1

      See identical proteins and their annotated locations for XP_006520094.1

      Conserved Domains (2) summary
      cl10011
      Location:1187
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
      cl25995
      Location:217248
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase