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    Pdlim2 PDZ and LIM domain 2 [ Mus musculus (house mouse) ]

    Gene ID: 213019, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pdlim2provided by MGI
    Official Full Name
    PDZ and LIM domain 2provided by MGI
    Primary source
    MGI:MGI:2384850
    See related
    Ensembl:ENSMUSG00000022090 AllianceGenome:MGI:2384850
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Slim; 4732462F18Rik
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in protein catabolic process. Predicted to be located in cortical actin cytoskeleton. Predicted to be part of filamentous actin. Predicted to be active in Z disc; adherens junction; and stress fiber. Is expressed in embryo. Orthologous to human PDLIM2 (PDZ and LIM domain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 101.4), small intestine adult (RPKM 50.1) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pdlim2 in Genome Data Viewer
    Location:
    14 D2; 14 36.26 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70401667..70415140, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70162621..70177672, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9930012K11 gene Neighboring gene cell cycle activator and apoptosis regulator 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70553578-70553761 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70559515-70559758 Neighboring gene STARR-positive B cell enhancer ABC_E7331 Neighboring gene sorbin and SH3 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E10833 Neighboring gene predicted gene, 26908 Neighboring gene protein phosphatase 3, catalytic subunit, gamma isoform Neighboring gene predicted gene, 33790

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC37634

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables alpha-actinin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables filamin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables filamin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables muscle alpha-actinin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables muscle alpha-actinin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables muscle alpha-actinin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables myosin heavy chain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin heavy chain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in muscle structure development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    part_of filamentous actin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
     
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    PDZ and LIM domain protein 2
    Names
    PDZ-LIM protein mystique
    STAT-interacting LIM protein
    mystique

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253736.1NP_001240665.1  PDZ and LIM domain protein 2

      See identical proteins and their annotated locations for NP_001240665.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC151836, BE634101, BY072232, DV646822
      Consensus CDS
      CCDS27248.1
      UniProtKB/Swiss-Prot
      Q8R1G6
      Related
      ENSMUSP00000116200.2, ENSMUST00000153735.8
      Conserved Domains (3) summary
      cd09449
      Location:283335
      LIM_Mystique; The LIM domain of Mystique, a subfamily of ALP LIM domain proteins
      cd00992
      Location:980
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:198252
      DUF4749; Domain of unknown function (DUF4749)
    2. NM_145978.2NP_666090.1  PDZ and LIM domain protein 2

      See identical proteins and their annotated locations for NP_666090.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same protein.
      Source sequence(s)
      AC151836
      Consensus CDS
      CCDS27248.1
      UniProtKB/Swiss-Prot
      Q8R1G6
      Related
      ENSMUSP00000022681.5, ENSMUST00000022681.11
      Conserved Domains (3) summary
      cd09449
      Location:283335
      LIM_Mystique; The LIM domain of Mystique, a subfamily of ALP LIM domain proteins
      cd00992
      Location:980
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:198252
      DUF4749; Domain of unknown function (DUF4749)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      70401667..70415140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247711.2XP_030103571.1  PDZ and LIM domain protein 2 isoform X3

      Conserved Domains (3) summary
      cd09449
      Location:246298
      LIM_Mystique; The LIM domain of Mystique, a subfamily of ALP LIM domain proteins
      cd00992
      Location:980
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:153215
      DUF4749; Domain of unknown function (DUF4749)
    2. XM_030247710.2XP_030103570.1  PDZ and LIM domain protein 2 isoform X2

      Conserved Domains (3) summary
      cd09449
      Location:282334
      LIM_Mystique; The LIM domain of Mystique, a subfamily of ALP LIM domain proteins
      cd00992
      Location:980
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:190251
      DUF4749; Domain of unknown function (DUF4749)
    3. XM_036158534.1XP_036014427.1  PDZ and LIM domain protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8R1G6
      Conserved Domains (3) summary
      cd09449
      Location:283335
      LIM_Mystique; The LIM domain of Mystique, a subfamily of ALP LIM domain proteins
      cd00992
      Location:980
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:198252
      DUF4749; Domain of unknown function (DUF4749)
    4. XM_006518783.5XP_006518846.1  PDZ and LIM domain protein 2 isoform X4

      Conserved Domains (2) summary
      cd09449
      Location:224276
      LIM_Mystique; The LIM domain of Mystique, a subfamily of ALP LIM domain proteins
      pfam15936
      Location:141193
      DUF4749; Domain of unknown function (DUF4749)