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    Rad51c RAD51 paralog C [ Mus musculus (house mouse) ]

    Gene ID: 114714, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rad51cprovided by MGI
    Official Full Name
    RAD51 paralog Cprovided by MGI
    Primary source
    MGI:MGI:2150020
    See related
    Ensembl:ENSMUSG00000007646 AllianceGenome:MGI:2150020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    R51H3; Rad51l2
    Summary
    Enables crossover junction DNA endonuclease activity. Involved in telomere maintenance via recombination. Acts upstream of or within female meiosis sister chromatid cohesion; meiosis I; and spermatogenesis. Located in nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group O and hereditary breast ovarian cancer syndrome. Orthologous to human RAD51C (RAD51 paralog C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 3.5), CNS E11.5 (RPKM 2.8) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rad51c in Genome Data Viewer
    Location:
    11 C; 11 52.08 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87267471..87295780, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87376645..87404954, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 37 Neighboring gene STARR-seq mESC enhancer starr_30287 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87059058-87059211 Neighboring gene protein phosphatase 1E (PP2C domain containing) Neighboring gene predicted gene, 33937 Neighboring gene predicted gene, 22883 Neighboring gene STARR-positive B cell enhancer ABC_E3005 Neighboring gene VISTA enhancer mm264 Neighboring gene STARR-positive B cell enhancer mm9_chr11:87239792-87240093 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87240340-87240523 Neighboring gene testis expressed gene 14 intercellular bridge forming factor Neighboring gene predicted gene, 22068 Neighboring gene U1a1 small nuclear RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to crossover junction DNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables crossover junction DNA endonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contributes_to crossover junction DNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to four-way junction DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to four-way junction DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to four-way junction DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within female meiosis sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in meiotic DNA recombinase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of G2/M transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in telomere maintenance via recombination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Holliday junction resolvase complex IC
    Inferred by Curator
    more info
    PubMed 
    part_of Rad51B-Rad51C-Rad51D-XRCC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Rad51B-Rad51C-Rad51D-XRCC2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Rad51B-Rad51C-Rad51D-XRCC2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of Rad51C-XRCC3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Rad51C-XRCC3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Rad51C-XRCC3 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in replication fork ISO
    Inferred from Sequence Orthology
    more info
     
    located_in replication fork ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    DNA repair protein RAD51 homolog 3
    Names
    RAD51 homolog C
    RAD51-like protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291440.2NP_001278369.1  DNA repair protein RAD51 homolog 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596130, AL669902
      Consensus CDS
      CCDS79013.1
      UniProtKB/Swiss-Prot
      Q924H5
      Related
      ENSMUSP00000007790.5, ENSMUST00000007790.11
      Conserved Domains (2) summary
      cd01123
      Location:109356
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
      pfam08423
      Location:95358
      Rad51; Rad51
    2. NM_053269.4NP_444499.1  DNA repair protein RAD51 homolog 3 isoform 2

      See identical proteins and their annotated locations for NP_444499.1

      Status: VALIDATED

      Source sequence(s)
      AL596130, AL669902, BC090648, BY720217
      Consensus CDS
      CCDS25212.1
      UniProtKB/Swiss-Prot
      B2KGK7, Q5SX32, Q8C653, Q924H5
      UniProtKB/TrEMBL
      F2Z433
      Related
      ENSMUSP00000064079.7, ENSMUST00000067692.13
      Conserved Domains (2) summary
      PRK04301
      Location:12340
      radA; DNA repair and recombination protein RadA; Validated
      cd01123
      Location:91338
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...

    RNA

    1. NR_156495.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK136204, AL596130, AL669902

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      87267471..87295780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156234.1XP_036012127.1  DNA repair protein RAD51 homolog 3 isoform X1

    2. XM_036156235.1XP_036012128.1  DNA repair protein RAD51 homolog 3 isoform X2

      Conserved Domains (2) summary
      PRK04301
      Location:12166
      radA; DNA repair and recombination protein RadA; Validated
      cl38936
      Location:109226
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases