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    Rfc5 replication factor C (activator 1) 5 [ Mus musculus (house mouse) ]

    Gene ID: 72151, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rfc5provided by MGI
    Official Full Name
    replication factor C (activator 1) 5provided by MGI
    Primary source
    MGI:MGI:1919401
    See related
    Ensembl:ENSMUSG00000029363 AllianceGenome:MGI:1919401
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    36kDa; Recc5; 36.5kDa; 2610020K06Rik; 2610209F07Rik
    Summary
    Enables enzyme binding activity. Predicted to be involved in DNA repair; DNA-templated DNA replication; and positive regulation of DNA-directed DNA polymerase activity. Predicted to be part of Ctf18 RFC-like complex and DNA replication factor C complex. Predicted to be active in nucleus. Orthologous to human RFC5 (replication factor C subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 17.2), liver E14.5 (RPKM 16.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rfc5 in Genome Data Viewer
    Location:
    5 F; 5 56.88 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (117517210..117527088, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (117379145..117389023, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14176 Neighboring gene predicted gene, 42012 Neighboring gene WD repeat and SOCS box-containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:117838823-117838932 Neighboring gene STARR-positive B cell enhancer ABC_E6370 Neighboring gene STARR-seq mESC enhancer starr_14179 Neighboring gene predicted gene 15728 Neighboring gene STARR-seq mESC enhancer starr_14180 Neighboring gene STARR-seq mESC enhancer starr_14181 Neighboring gene STARR-seq mESC enhancer starr_14183 Neighboring gene predicted gene, 52829

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. cDNAs encoding the large subunit of human replication factor C. Bunz F, et al. Proc Natl Acad Sci U S A, 1993 Dec 1. PMID 8248204, Free PMC Article
    2. RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication. Vannier JB, et al. Science, 2013 Oct 11. PMID 24115439
    3. Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Cirilli M, et al. Biochim Biophys Acta Gen Subj, 2017 Feb. PMID 27746211
    4. Affinity purification strategies for proteomic analysis of transcription factor complexes. Giambruno R, et al. J Proteome Res, 2013 Sep 6. PMID 23937658, Free PMC Article
    5. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, et al. PLoS One, 2011 May 12. PMID 21589869, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC113787

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA clamp loader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to DNA clamp loader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to DNA clamp loader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to single-stranded DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to single-stranded DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-directed DNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Ctf18 RFC-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Ctf18 RFC-like complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of DNA replication factor C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DNA replication factor C complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    replication factor C subunit 5
    Names
    A1 36 kDa subunit
    RF-C 36 kDa subunit
    RFC36
    activator 1 36 kDa subunit
    activator 1 subunit 5
    replication factor C 36 kDa subunit
    replication factor C 5
    replication factor C, 36 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028128.1 → NP_082404.1  replication factor C subunit 5

      See identical proteins and their annotated locations for NP_082404.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089001
      Consensus CDS
      CCDS39235.1
      UniProtKB/Swiss-Prot
      Q9D0F6
      UniProtKB/TrEMBL
      Q3UDK3, Q5HZI8
      Related
      ENSMUSP00000083652.7, ENSMUST00000086461.13
      Conserved Domains (4) summary
      cd00009
      Location:34 → 175
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      PRK00440
      Location:17 → 328
      rfc; replication factor C small subunit; Reviewed
      pfam08542
      Location:257 → 326
      Rep_fac_C; Replication factor C C-terminal domain
      pfam16193
      Location:191 → 219
      AAA_assoc_2; AAA C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      117517210..117527088 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0F6.1 GenPept UniProtKB/Swiss-Prot:Q9D0F6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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