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    Sub1 SUB1 homolog, transcriptional regulator [ Mus musculus (house mouse) ]

    Gene ID: 20024, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sub1provided by MGI
    Official Full Name
    SUB1 homolog, transcriptional regulatorprovided by MGI
    Primary source
    MGI:MGI:104811
    See related
    Ensembl:ENSMUSG00000022205 AllianceGenome:MGI:104811
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P9; P15; Pc4; Rpo2tc1
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in RNA polymerase II promoter clearance; negative regulation of DNA duplex unwinding; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human SUB1 (SUB1 regulator of transcription). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 33.8), CNS E11.5 (RPKM 28.8) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Sub1 in Genome Data Viewer
    Location:
    15 A1; 15 5.9 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (11981422..11996091, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (11981336..11996038, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34618 Neighboring gene RIKEN cDNA 1700047G03 gene Neighboring gene STARR-positive B cell enhancer ABC_E7360 Neighboring gene SEC13 homolog pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8584 Neighboring gene STARR-positive B cell enhancer ABC_E3132 Neighboring gene STARR-positive B cell enhancer ABC_E7361 Neighboring gene STARR-seq mESC enhancer starr_38007 Neighboring gene predicted gene 2559 Neighboring gene predicted gene, 34759

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    activated RNA polymerase II transcriptional coactivator p15
    Names
    RNA polymerase II transcriptional coactivator
    p14
    positive cofactor 4
    single-stranded DNA-binding protein p9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411715.1NP_001398644.1  activated RNA polymerase II transcriptional coactivator p15

      Status: VALIDATED

      Source sequence(s)
      AC121860
      UniProtKB/Swiss-Prot
      P11031, Q3UJR5, Q543N2
    2. NM_011294.4NP_035424.1  activated RNA polymerase II transcriptional coactivator p15

      See identical proteins and their annotated locations for NP_035424.1

      Status: VALIDATED

      Source sequence(s)
      AC121860
      Consensus CDS
      CCDS27387.1
      UniProtKB/Swiss-Prot
      P11031, Q3UJR5, Q543N2
      Related
      ENSMUSP00000022816.9, ENSMUST00000022816.15
      Conserved Domains (1) summary
      pfam02229
      Location:68115
      PC4; Transcriptional Coactivator p15 (PC4)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      11981422..11996091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)