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    Slc17a6 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 [ Mus musculus (house mouse) ]

    Gene ID: 140919, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc17a6provided by MGI
    Official Full Name
    solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6provided by MGI
    Primary source
    MGI:MGI:2156052
    See related
    Ensembl:ENSMUSG00000030500 AllianceGenome:MGI:2156052
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DNPI; VGLUT2; 2900073D12Rik
    Summary
    Enables L-glutamate uniporter activity; potassium:proton antiporter activity; and sodium:phosphate symporter activity. Involved in several processes, including L-glutamate transmembrane transport; hyaloid vascular plexus regression; and sodium-dependent phosphate transport. Acts upstream of or within neurotransmitter uptake. Located in synaptic vesicle. Is expressed in several structures, including cranial ganglion; nervous system; sensory organ; tail mesenchyme; and testis. Orthologous to human SLC17A6 (solute carrier family 17 member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 12.2), whole brain E14.5 (RPKM 12.1) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Slc17a6 in Genome Data Viewer
    Location:
    7 B4; 7 32.78 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (51271578..51320874)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (51621830..51671126)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18928 Neighboring gene predicted gene 9354 Neighboring gene predicted gene, 33190 Neighboring gene anoctamin 5 Neighboring gene predicted gene, 33136 Neighboring gene predicted gene, 42402 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-glutamate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-glutamate uniporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-glutamate uniporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-glutamate uniporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chloride channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables neurotransmitter transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables potassium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables potassium:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium:phosphate symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sodium:phosphate symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in L-glutamate import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-glutamate import ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in L-glutamate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in L-glutamate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hyaloid vascular plexus regression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurotransmitter loading into synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neurotransmitter loading into synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neurotransmitter uptake IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphate ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphate ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphate ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphate ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synapse structure or activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium-dependent phosphate transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sodium-dependent phosphate transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium-dependent phosphate transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in excitatory synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in pericellular basket ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    vesicular glutamate transporter 2
    Names
    differentiation-associated BNPI
    differentiation-associated Na(+)-dependent inorganic phosphate cotransporter
    solute carrier family 17 (vesicular glutamate transporter), member 6
    solute carrier family 17 member 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355150.1NP_001342079.1  vesicular glutamate transporter 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113306, AC163335
      UniProtKB/Swiss-Prot
      Q8BLE7, Q920B7
      Conserved Domains (1) summary
      cl27298
      Location:1436
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]
    2. NM_080853.3NP_543129.3  vesicular glutamate transporter 2 isoform 1

      See identical proteins and their annotated locations for NP_543129.3

      Status: VALIDATED

      Source sequence(s)
      AF324864, BB304814, BC038375, CB519039, CD578992
      Consensus CDS
      CCDS39969.1
      UniProtKB/Swiss-Prot
      Q8BLE7, Q920B7
      UniProtKB/TrEMBL
      A0A0R4J0A6
      Related
      ENSMUSP00000032710.6, ENSMUST00000032710.7
      Conserved Domains (2) summary
      cd06174
      Location:75498
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:70511
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      51271578..51320874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540601.5XP_006540664.1  vesicular glutamate transporter 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8BLE7, Q920B7
      Conserved Domains (1) summary
      cd17382
      Location:47471
      MFS_SLC17A6_7_8_VGluT; Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters