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    Tars1 threonyl-tRNA synthetase 1 [ Mus musculus (house mouse) ]

    Gene ID: 110960, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tars1provided by MGI
    Official Full Name
    threonyl-tRNA synthetase 1provided by MGI
    Primary source
    MGI:MGI:106314
    See related
    Ensembl:ENSMUSG00000022241 AllianceGenome:MGI:106314
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tars; ThrRS; D15Wsu59e
    Summary
    Enables threonine-tRNA ligase activity. Involved in threonyl-tRNA aminoacylation. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; integumental system; liver; and sensory organ. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 7. Orthologous to human TARS1 (threonyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 35.0), liver E14 (RPKM 27.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tars1 in Genome Data Viewer
    Location:
    15 A1; 15 5.6 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (11383749..11399744, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (11383663..11399658, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 12 Neighboring gene STARR-seq mESC enhancer starr_37989 Neighboring gene STARR-seq mESC enhancer starr_37990 Neighboring gene STARR-seq mESC enhancer starr_37991 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:11329613-11329796 Neighboring gene STARR-positive B cell enhancer ABC_E5468 Neighboring gene STARR-seq mESC enhancer starr_37992 Neighboring gene predicted gene, 34444 Neighboring gene predicted gene, 24844 Neighboring gene STARR-seq mESC enhancer starr_37993 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:11462766-11462983 Neighboring gene STARR-positive B cell enhancer ABC_E9908 Neighboring gene STARR-seq mESC enhancer starr_37995 Neighboring gene STARR-seq mESC enhancer starr_37996 Neighboring gene STARR-seq mESC enhancer starr_37998 Neighboring gene STARR-seq mESC enhancer starr_37999 Neighboring gene predicted gene, 41271 Neighboring gene predicted gene, 41272

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables threonine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables threonine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables threonine-tRNA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables threonine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in threonyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in threonyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in threonyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    threonine--tRNA ligase 1, cytoplasmic
    Names
    threonine--tRNA ligase, cytoplasmic
    threonyl-tRNA synthetase, cytoplasmic
    NP_149065.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033074.3NP_149065.2  threonine--tRNA ligase 1, cytoplasmic

      See identical proteins and their annotated locations for NP_149065.2

      Status: PROVISIONAL

      Source sequence(s)
      AK011146
      Consensus CDS
      CCDS27385.1
      UniProtKB/Swiss-Prot
      Q3TL42, Q7TMQ2, Q8BMI6, Q9CX03, Q9D0R2
      UniProtKB/TrEMBL
      Q3U630
      Related
      ENSMUSP00000022849.6, ENSMUST00000022849.7
      Conserved Domains (1) summary
      PLN02908
      Location:50715
      PLN02908; threonyl-tRNA synthetase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      11383749..11399744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)