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    Tex14 testis expressed gene 14 intercellular bridge forming factor [ Mus musculus (house mouse) ]

    Gene ID: 83560, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tex14provided by MGI
    Official Full Name
    testis expressed gene 14 intercellular bridge forming factorprovided by MGI
    Primary source
    MGI:MGI:1933227
    See related
    Ensembl:ENSMUSG00000010342 AllianceGenome:MGI:1933227
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable protein kinase binding activity. Involved in several processes, including intercellular bridge organization; mitotic spindle assembly checkpoint signaling; and nuclear chromosome segregation. Acts upstream of or within cellular response to leukemia inhibitory factor and negative regulation of cytokinesis. Located in intercellular bridge; kinetochore; and midbody. Is expressed in germ cell of ovary; germ cell of testis; ovary; and primordial germ cell of gonad. Human ortholog(s) of this gene implicated in spermatogenic failure 23. Orthologous to human TEX14 (testis expressed 14, intercellular bridge forming factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 6.6) and placenta adult (RPKM 0.2) See more
    Orthologs
    NEW
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    Genomic context

    See Tex14 in Genome Data Viewer
    Location:
    11 C; 11 52.09 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87295839..87446649)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87405013..87555823)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1E (PP2C domain containing) Neighboring gene predicted gene, 33937 Neighboring gene predicted gene, 22883 Neighboring gene STARR-positive B cell enhancer ABC_E3005 Neighboring gene RAD51 paralog C Neighboring gene VISTA enhancer mm264 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87240340-87240523 Neighboring gene STARR-positive B cell enhancer mm9_chr11:87239792-87240093 Neighboring gene STARR-positive B cell enhancer ABC_E3990 Neighboring gene STARR-positive B cell enhancer mm9_chr11:87257185-87257486 Neighboring gene STARR-positive B cell enhancer mm9_chr11:87261696-87261996 Neighboring gene STARR-positive B cell enhancer mm9_chr11:87262254-87262555 Neighboring gene predicted gene, 22068 Neighboring gene U1a1 small nuclear RNA Neighboring gene STARR-positive B cell enhancer ABC_E3992 Neighboring gene small nucleolar RNA, C/D box 3B1 Neighboring gene predicted gene, 57580 Neighboring gene small nucleolar RNA, C/D box 3B3 Neighboring gene predicted gene, 23137 Neighboring gene STARR-seq mESC enhancer starr_30291 Neighboring gene small nucleolar RNA, C/D box 3B4 Neighboring gene small nucleolar RNA, C/D box 3B2 Neighboring gene STARR-seq mESC enhancer starr_30292 Neighboring gene predicted gene, 34000 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87405102-87405211 Neighboring gene STARR-positive B cell enhancer ABC_E68 Neighboring gene septin 4 Neighboring gene STARR-seq mESC enhancer starr_30293 Neighboring gene myotubularin related protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in intercellular bridge organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intercellular bridge organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in male meiotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic sister chromatid separation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic sister chromatid separation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cytokinesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in intercellular bridge IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    inactive serine/threonine-protein kinase TEX14
    Names
    testis-expressed protein 14
    testis-expressed sequence 14 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199293.1NP_001186222.1  inactive serine/threonine-protein kinase TEX14 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform a).
      Source sequence(s)
      AL669902, BK000967
      UniProtKB/Swiss-Prot
      Q7M6U3
      Conserved Domains (5) summary
      COG0515
      Location:269632
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00204
      Location:39137
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:39131
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:6798
      ANK; ANK repeat [structural motif]
      cl21453
      Location:282519
      PKc_like; Protein Kinases, catalytic domain
    2. NM_031386.2NP_113563.2  inactive serine/threonine-protein kinase TEX14 isoform b

      See identical proteins and their annotated locations for NP_113563.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different first exon which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform b) has a shorter N-terminus when it is compared to isoform a.
      Source sequence(s)
      AL669902, BK000966
      Consensus CDS
      CCDS48877.1
      UniProtKB/Swiss-Prot
      B2KGL0, Q3UT36, Q5NC10, Q5NC11, Q7M6U3, Q8CGK1, Q8CGK2, Q99MV8
      Related
      ENSMUSP00000054444.6, ENSMUST00000060835.12
      Conserved Domains (5) summary
      COG0515
      Location:257620
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00204
      Location:27125
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:27119
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:5586
      ANK; ANK repeat [structural motif]
      cl21453
      Location:270507
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      87295839..87446649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249327.3XP_011247629.1  inactive serine/threonine-protein kinase TEX14 isoform X1

      See identical proteins and their annotated locations for XP_011247629.1

      Conserved Domains (5) summary
      PTZ00322
      Location:72179
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      COG5214
      Location:458658
      POL12; DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]
      sd00045
      Location:5586
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:27119
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:270507
      PKc_like; Protein Kinases, catalytic domain
    2. XM_017314856.2XP_017170345.1  inactive serine/threonine-protein kinase TEX14 isoform X3

      Conserved Domains (5) summary
      PTZ00322
      Location:72179
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      COG5214
      Location:458658
      POL12; DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]
      sd00045
      Location:5586
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:27119
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:270507
      PKc_like; Protein Kinases, catalytic domain
    3. XM_017314855.2XP_017170344.1  inactive serine/threonine-protein kinase TEX14 isoform X2

      Conserved Domains (5) summary
      PTZ00322
      Location:72179
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      COG5214
      Location:458658
      POL12; DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]
      sd00045
      Location:5586
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:27119
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:270507
      PKc_like; Protein Kinases, catalytic domain
    4. XM_017314857.2XP_017170346.1  inactive serine/threonine-protein kinase TEX14 isoform X4

      Conserved Domains (5) summary
      PTZ00322
      Location:72179
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      COG5214
      Location:458658
      POL12; DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]
      sd00045
      Location:5586
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:27119
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:270507
      PKc_like; Protein Kinases, catalytic domain
    5. XM_017314858.2XP_017170347.1  inactive serine/threonine-protein kinase TEX14 isoform X7

      Conserved Domains (5) summary
      PTZ00322
      Location:72179
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      COG5214
      Location:458658
      POL12; DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]
      sd00045
      Location:5586
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:27119
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:270507
      PKc_like; Protein Kinases, catalytic domain
    6. XM_011249328.3XP_011247630.1  inactive serine/threonine-protein kinase TEX14 isoform X5

      See identical proteins and their annotated locations for XP_011247630.1

      Conserved Domains (2) summary
      COG5214
      Location:240440
      POL12; DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]
      cl21453
      Location:52289
      PKc_like; Protein Kinases, catalytic domain
    7. XM_011249329.1XP_011247631.1  inactive serine/threonine-protein kinase TEX14 isoform X6

      See identical proteins and their annotated locations for XP_011247631.1

      Conserved Domains (2) summary
      COG5214
      Location:169369
      POL12; DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]
      cl21453
      Location:7218
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_001780081.2 RNA Sequence