Ubash3a ubiquitin associated and SH3 domain containing, A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ubash3aprovided by MGI
Official Full Name: ubiquitin associated and SH3 domain containing, Aprovided by MGI
Primary source: MGI:MGI:1926074
See related: Ensembl:ENSMUSG00000042345 AllianceGenome:MGI:1926074
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TULA; Sts-2; TULA-1; C330001M22; 5830413C03Rik
Summary: Acts upstream of or within negative regulation of T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in cytosol and nuclear speck. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skin. Orthologous to human UBASH3A (ubiquitin associated and SH3 domain containing A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thymus adult (RPKM 15.3), liver E14.5 (RPKM 3.3) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3- B1; 17 15.84 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (31426842..31478655)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (31207868..31259681)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice.
Title: UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice.
Bone marrow-derived dendritic cells (BMDCs) lacking ubiquitin associated and SH3 domain containing A (Sts-2) expression have an enhanced ability to inhibit Candida albicans growth and contribute significantly to the resistance of Sts-/- mice. Within BMDCs, the Sts phosphatases negatively regulate the activation of select pathways downstream of the key fungal pathogen pattern recognition receptor Dectin-1.
Title: Phagocytes from Mice Lacking the Sts Phosphatases Have an Enhanced Antifungal Response to Candida albicans.
STS-2 suppresses development of collagen-induced arthritis.
Title: Suppressor of TCR signaling-2 (STS-2) suppresses arthritis development in mice.
Herein, the authors demonstrate that mice lacking Sts expression are significantly resistant to infection by the live vaccine strain of Francisella tularensis.
Title: Increased Resistance to Intradermal Francisella tularensis LVS Infection by Inactivation of the Sts Phosphatases.
Sts-1 and Sts-2 are not required for the immune control of murine herpesvirus 68 in a normal course of gammaherpesvirus infection.
Title: Enhanced response of T cells from murine gammaherpesvirus 68-infected mice lacking the suppressor of T cell receptor signaling molecules Sts-1 and Sts-2.
Biochemical analysis identified STS-1 and STS-2 as direct phosphatases of FLT3 and c-KIT.
Title: The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.
The lack of TULA facilitates T-cell responses to TCR/CD3 stimulation, thus exacerbating T-cell-dependent inflammation.
Title: Members of the novel UBASH3/STS/TULA family of cellular regulators suppress T-cell-driven inflammatory responses in vivo.
Skeletal analysis of mice that do not express TULA or TULA-2 proteins (DKO mice) revealed that there was a decrease in bone volume due to increased osteoclast numbers and function.
Title: TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function.
Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 and T cell receptor signaling pathways.
Title: Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 and T cell receptor signaling pathways.
Sts-2(phosphoglycerate mutase) adopts the conformation of an active phosphatase whose activity is fundamentally different from that of Sts-1 despite the strong structural homology.
Title: Structural and functional characterization of the 2H-phosphatase domain of Sts-2 reveals an acid-dependent phosphatase activity.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (3) 1 citation

General gene information

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Markers

Ubash3a (e-PCR), detects polymorphism
- UniSTS:259669

Ubash3a (e-PCR), detects polymorphism
- UniSTS:259166

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within collagen-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of T cell receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
NOT acts_upstream_of_or_within platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cytokine production	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin-associated and SH3 domain-containing protein A

Names: T-cell ubiquitin ligand 1; suppressor of T-cell receptor signaling 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177823.4 → NP_808491.2 ubiquitin-associated and SH3 domain-containing protein A

Status: VALIDATED

Source sequence(s)

AK040572, BB736706, BC027561, BY227020

Consensus CDS

CCDS50054.1

UniProtKB/Swiss-Prot

Q3TED7, Q3V3E1

Related

ENSMUSP00000158544.2, ENSMUST00000236745.2

Conserved Domains (4) summary

cd07040
Location:361 → 456

HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

cd11937
Location:241 → 300

SH3_UBASH3A; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein A

cd14300
Location:25 → 61

UBA_UBS3A_like; UBA domain found in ubiquitin-associated and SH3 domain-containing protein A (UBS3A) and similar proteins

pfam00300
Location:413 → 575

His_Phos_1; Histidine phosphatase superfamily (branch 1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

31426842..31478655

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524434.5 → XP_006524497.1 ubiquitin-associated and SH3 domain-containing protein A isoform X1

UniProtKB/TrEMBL

A0A498WGR9

Related

ENSMUSP00000045890.9, ENSMUST00000048656.15

Conserved Domains (3) summary

cd07067
Location:361 → 476

HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

cd11937
Location:241 → 300

SH3_UBASH3A; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein A

cd14300
Location:25 → 61

UBA_UBS3A_like; UBA domain found in ubiquitin-associated and SH3 domain-containing protein A (UBS3A) and similar proteins