Zfyve9 zinc finger, FYVE domain containing 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfyve9provided by MGI
Official Full Name: zinc finger, FYVE domain containing 9provided by MGI
Primary source: MGI:MGI:2652838
See related: Ensembl:ENSMUSG00000034557 AllianceGenome:MGI:2652838
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NSP; SARA; Madhip; SMADIP
Summary: Predicted to enable 1-phosphatidylinositol binding activity; SMAD binding activity; and protein domain specific binding activity. Predicted to be involved in endosomal transport and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of protein-containing complex. Predicted to be active in early endosome membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human ZFYVE9 (zinc finger FYVE-type containing 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 7.6), cortex adult (RPKM 4.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C7; 4 50.64 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (108494663..108642514, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (108637466..108781269, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study describes the expression of two SARA isoforms, SARA1 and SARA2, in mice and reports the generation and characterization of SARA mutant mice with FYVE domain deletion. The loss of SARA promoted skin tumor formation and malignant progression.
Title: The FYVE domain of Smad Anchor for Receptor Activation (SARA) is required to prevent skin carcinogenesis, but not in mouse development.
osteoblast targeted expression of a mutant endofin protein lacking the pp1c binding activity results in sustained signaling of the BMP type I receptor, which increases bone formation and skeletal angiogenesis.
Title: Sustained BMP signaling in osteoblasts stimulates bone formation by promoting angiogenesis and osteoblast differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endosomal transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in early endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger FYVE domain-containing protein 9

Names: MAD, mothers against decapentaplegic homolog interacting protein, receptor activation anchor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347163.2 → NP_001334092.1 zinc finger FYVE domain-containing protein 9 isoform 1

Status: VALIDATED

Source sequence(s)

AL607070, AL626783, AL671909

Consensus CDS

CCDS84772.1

UniProtKB/TrEMBL

A2A8R0

Conserved Domains (3) summary

cd15729
Location:662 → 729

FYVE_endofin; FYVE domain found in endofin and similar proteins

pfam11409
Location:745 → 783

SARA; Smad anchor for receptor activation (SARA)

pfam11979
Location:1020 → 1372

DUF3480; Domain of unknown function (DUF3480)
NM_001384118.1 → NP_001371047.1 zinc finger FYVE domain-containing protein 9 isoform 1

Status: VALIDATED

Source sequence(s)

AL607070, AL626783, AL671909

UniProtKB/TrEMBL

A2A8R0

Related

ENSMUSP00000102268.2, ENSMUST00000106657.8

Conserved Domains (3) summary

cd15729
Location:662 → 729

FYVE_endofin; FYVE domain found in endofin and similar proteins

pfam11409
Location:745 → 783

SARA; Smad anchor for receptor activation (SARA)

pfam11979
Location:1020 → 1372

DUF3480; Domain of unknown function (DUF3480)
NM_001426209.1 → NP_001413138.1 zinc finger FYVE domain-containing protein 9 isoform 3

Status: VALIDATED

Source sequence(s)

AL607070, AL626783, AL671909

UniProtKB/TrEMBL

A8Y5G5

Related

ENSMUSP00000102269.2, ENSMUST00000106658.8
NM_001426210.1 → NP_001413139.1 zinc finger FYVE domain-containing protein 9 isoform 4

Status: VALIDATED

Source sequence(s)

AL607070, AL626783, AL671909
NM_001426211.1 → NP_001413140.1 zinc finger FYVE domain-containing protein 9 isoform 5

Status: VALIDATED

Source sequence(s)

AL607070, AL626783, AL671909
NM_183300.4 → NP_899123.2 zinc finger FYVE domain-containing protein 9 isoform 2

See identical proteins and their annotated locations for NP_899123.2

Status: VALIDATED

Source sequence(s)

AL607070, AL626783, AL671909

Consensus CDS

CCDS38834.1

UniProtKB/TrEMBL

A0S860

Related

ENSMUSP00000039852.8, ENSMUST00000042185.8

Conserved Domains (3) summary

pfam11409
Location:54 → 92

SARA; Smad anchor for receptor activation (SARA)

pfam11979
Location:329 → 681

DUF3480; Domain of unknown function (DUF3480)

cl22851
Location:7 → 38

PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

108494663..108642514 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502986.5 → XP_006503049.1 zinc finger FYVE domain-containing protein 9 isoform X1

Conserved Domains (3) summary

cd15729
Location:696 → 763

FYVE_endofin; FYVE domain found in endofin and similar proteins

pfam11409
Location:779 → 817

SARA; Smad anchor for receptor activation (SARA)

pfam11979
Location:1054 → 1406

DUF3480; Domain of unknown function (DUF3480)
XM_006502988.5 → XP_006503051.1 zinc finger FYVE domain-containing protein 9 isoform X3

Conserved Domains (2) summary

cd15729
Location:696 → 763

FYVE_endofin; FYVE domain found in endofin and similar proteins

pfam11979
Location:995 → 1347

DUF3480; Domain of unknown function (DUF3480)
XM_030253438.2 → XP_030109298.1 zinc finger FYVE domain-containing protein 9 isoform X2

Conserved Domains (3) summary

cd15729
Location:696 → 763

FYVE_endofin; FYVE domain found in endofin and similar proteins

pfam11409
Location:779 → 817

SARA; Smad anchor for receptor activation (SARA)

pfam11979
Location:1054 → 1379

DUF3480; Domain of unknown function (DUF3480)