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    PROSER3 proline and serine rich 3 [ Homo sapiens (human) ]

    Gene ID: 148137, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PROSER3provided by HGNC
    Official Full Name
    proline and serine rich 3provided by HGNC
    Primary source
    HGNC:HGNC:25204
    See related
    Ensembl:ENSG00000167595 AllianceGenome:HGNC:25204
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C19orf55
    Summary
    Located in centrosome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 6.2), appendix (RPKM 2.0) and 24 other tissues See more
    Orthologs
    mouse all
    NEW
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    Genomic context

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    See PROSER3 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35758176..35771166)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38303488..38317285)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36249077..36262068)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36239246-36239760 Neighboring gene lin-37 DREAM MuvB core complex component Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36248182-36248753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14501 Neighboring gene heat shock protein family B (small) member 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36257953-36258804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14502 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10539 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36268039-36268924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36268925-36269809 Neighboring gene Rho GTPase activating protein 33 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36275082-36275900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14503 Neighboring gene testis expressed 14B, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway. Xu G, et al. Cell Death Dis, 2023 Feb 27. PMID 36849460, Free PMC Article
    2. An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity. Zhang Y, et al. Cell Chem Biol, 2022 Jan 20. PMID 34672954, Free PMC Article
    3. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Gordon DE, et al. Science, 2020 Dec 4. PMID 33060197, Free PMC Article
    4. The human cytoplasmic dynein interactome reveals novel activators of motility. Redwine WB, et al. Elife, 2017 Jul 18. PMID 28718761, Free PMC Article
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ30657, MGC131952, DKFZp434C2231

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    proline and serine-rich protein 3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039887.3 → NP_001034976.2  proline and serine-rich protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001034976.2

      Status: VALIDATED

      Source sequence(s)
      AC002398, BC110893, DB086668
      Consensus CDS
      CCDS46056.2
      UniProtKB/Swiss-Prot
      Q2NL68, Q8NDI3, Q8WWC8, Q96NL4
      Related
      ENSP00000380116.5, ENST00000396908.9

    2. NM_001367856.1 → NP_001354785.1  proline and serine-rich protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC002398, KF495725
      Consensus CDS
      CCDS92595.1
      UniProtKB/TrEMBL
      A0A2R8Y8D9
      Related
      ENSP00000496769.2, ENST00000646935.2
      Conserved Domains (2) summary
      PHA03247
      Location:267 → 616
      PHA03247; large tegument protein UL36; Provisional
      PRK14951
      Location:393 → 512
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional

    3. NM_001395450.1 → NP_001382379.1  proline and serine-rich protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC002398, KF495725
      Conserved Domains (1) summary
      PHA03247
      Location:244 → 615
      PHA03247; large tegument protein UL36; Provisional

    4. NM_001395451.1 → NP_001382380.1  proline and serine-rich protein 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC002398, KF495725
      Conserved Domains (2) summary
      PHA03247
      Location:229 → 604
      PHA03247; large tegument protein UL36; Provisional
      PRK14951
      Location:381 → 500
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional

    5. NM_001395452.1 → NP_001382381.1  proline and serine-rich protein 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC002398, KF495725
      Conserved Domains (1) summary
      PHA03247
      Location:159 → 530
      PHA03247; large tegument protein UL36; Provisional

    6. NM_001395453.1 → NP_001382382.1  proline and serine-rich protein 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC002398, KF495725
      Conserved Domains (1) summary
      PHA03247
      Location:149 → 520
      PHA03247; large tegument protein UL36; Provisional

    7. NM_001395454.1 → NP_001382383.1  proline and serine-rich protein 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC002398, KF495725
      Conserved Domains (1) summary
      PHA03247
      Location:134 → 505
      PHA03247; large tegument protein UL36; Provisional

    8. NM_001395455.1 → NP_001382384.1  proline and serine-rich protein 3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC002398, KF495725

    9. NM_001395456.1 → NP_001382385.1  proline and serine-rich protein 3 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC002398
      UniProtKB/TrEMBL
      C9JFW7
      Related
      ENSP00000301165.5, ENST00000301165.9

    10. NM_001395457.1 → NP_001382386.1  proline and serine-rich protein 3 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC002398

    11. NM_001395458.1 → NP_001382387.1  proline and serine-rich protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC002398, KF495725
      Consensus CDS
      CCDS92595.1
      UniProtKB/TrEMBL
      A0A2R8Y8D9
      Conserved Domains (2) summary
      PHA03247
      Location:267 → 616
      PHA03247; large tegument protein UL36; Provisional
      PRK14951
      Location:393 → 512
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      35758176..35771166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438263.1 → XP_047294219.1  proline and serine-rich protein 3 isoform X12

    2. XM_011526533.4 → XP_011524835.1  proline and serine-rich protein 3 isoform X9

      See identical proteins and their annotated locations for XP_011524835.1

      Conserved Domains (1) summary
      PRK14951
      Location:400 → 519
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional

    3. XM_011526528.2 → XP_011524830.1  proline and serine-rich protein 3 isoform X1

      Conserved Domains (2) summary
      PRK12323
      Location:267 → 471
      PRK12323; DNA polymerase III subunits gamma and tau; Provisional
      PRK14951
      Location:400 → 519
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional

    4. XM_011526532.2 → XP_011524834.1  proline and serine-rich protein 3 isoform X8

      Conserved Domains (1) summary
      PRK14951
      Location:400 → 519
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional

    5. XM_011526530.2 → XP_011524832.1  proline and serine-rich protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8Q3WKY3
      Related
      ENSP00000512346.1, ENST00000696041.1
      Conserved Domains (1) summary
      PHA03247
      Location:267 → 616
      PHA03247; large tegument protein UL36; Provisional

    6. XM_011526531.2 → XP_011524833.1  proline and serine-rich protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A8Q3WKY6
      Related
      ENSP00000512347.1, ENST00000696042.1
      Conserved Domains (2) summary
      PRK12323
      Location:256 → 460
      PRK12323; DNA polymerase III subunits gamma and tau; Provisional
      PRK14951
      Location:389 → 508
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional

    7. XM_047438264.1 → XP_047294220.1  proline and serine-rich protein 3 isoform X13

    8. XM_047438259.1 → XP_047294215.1  proline and serine-rich protein 3 isoform X6

    9. XM_047438261.1 → XP_047294217.1  proline and serine-rich protein 3 isoform X10

    10. XM_011526529.4 → XP_011524831.1  proline and serine-rich protein 3 isoform X2

      Conserved Domains (2) summary
      PRK12323
      Location:266 → 470
      PRK12323; DNA polymerase III subunits gamma and tau; Provisional
      PRK14951
      Location:399 → 518
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional

    11. XM_047438258.1 → XP_047294214.1  proline and serine-rich protein 3 isoform X4

    12. XM_047438262.1 → XP_047294218.1  proline and serine-rich protein 3 isoform X11

    13. XM_047438260.1 → XP_047294216.1  proline and serine-rich protein 3 isoform X7

    14. XM_011526535.3 → XP_011524837.1  proline and serine-rich protein 3 isoform X14

      UniProtKB/TrEMBL
      A0A8Q3WKY7
      Related
      ENSP00000512345.1, ENST00000696040.1
      Conserved Domains (1) summary
      PHA03247
      Location:145 → 523
      PHA03247; large tegument protein UL36; Provisional

    15. XM_047438265.1 → XP_047294221.1  proline and serine-rich protein 3 isoform X15

    16. XM_047438267.1 → XP_047294223.1  proline and serine-rich protein 3 isoform X17

    17. XM_047438266.1 → XP_047294222.1  proline and serine-rich protein 3 isoform X16

    18. XM_011526536.4 → XP_011524838.1  proline and serine-rich protein 3 isoform X18

      UniProtKB/Swiss-Prot
      Q2NL68
      Related
      ENSP00000482508.1, ENST00000620918.4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      38303488..38317285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319979.1 → XP_054175954.1  proline and serine-rich protein 3 isoform X12

    2. XM_054319968.1 → XP_054175943.1  proline and serine-rich protein 3 isoform X1

    3. XM_054319970.1 → XP_054175945.1  proline and serine-rich protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8Q3WKY3

    4. XM_054319972.1 → XP_054175947.1  proline and serine-rich protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A8Q3WKY6

    5. XM_054319973.1 → XP_054175948.1  proline and serine-rich protein 3 isoform X6

    6. XM_054319969.1 → XP_054175944.1  proline and serine-rich protein 3 isoform X2

    7. XM_054319971.1 → XP_054175946.1  proline and serine-rich protein 3 isoform X4

    8. XM_054319974.1 → XP_054175949.1  proline and serine-rich protein 3 isoform X7

    9. XM_054319981.1 → XP_054175956.1  proline and serine-rich protein 3 isoform X14

      UniProtKB/TrEMBL
      A0A8Q3WKY7

    10. XM_054319976.1 → XP_054175951.1  proline and serine-rich protein 3 isoform X9

    11. XM_054319975.1 → XP_054175950.1  proline and serine-rich protein 3 isoform X8

    12. XM_054319980.1 → XP_054175955.1  proline and serine-rich protein 3 isoform X13

    13. XM_054319977.1 → XP_054175952.1  proline and serine-rich protein 3 isoform X10

    14. XM_054319978.1 → XP_054175953.1  proline and serine-rich protein 3 isoform X11

    15. XM_054319982.1 → XP_054175957.1  proline and serine-rich protein 3 isoform X15

    16. XM_054319984.1 → XP_054175959.1  proline and serine-rich protein 3 isoform X17

    17. XM_054319983.1 → XP_054175958.1  proline and serine-rich protein 3 isoform X16

    18. XM_054319985.1 → XP_054175960.1  proline and serine-rich protein 3 isoform X18

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_144692.1: Suppressed sequence

      Description
      NM_144692.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2NL68.1 GenPept UniProtKB/Swiss-Prot:Q2NL68

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