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    TEAD1 TEA domain transcription factor 1 [ Homo sapiens (human) ]

    Gene ID: 7003, updated on 10-Dec-2024

    Summary

    Official Symbol
    TEAD1provided by HGNC
    Official Full Name
    TEA domain transcription factor 1provided by HGNC
    Primary source
    HGNC:HGNC:11714
    See related
    Ensembl:ENSG00000187079 MIM:189967; AllianceGenome:HGNC:11714
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AA; REF1; TCF13; TEF-1; NTEF-1; TCF-13; TEAD-1
    Summary
    This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in fat (RPKM 17.6), esophagus (RPKM 16.7) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TEAD1 in Genome Data Viewer
    Location:
    11p15.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (12674421..12944737)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (12766927..13037265)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (12695968..12966284)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene parvin alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12474119-12474620 Neighboring gene Sharpr-MPRA regulatory region 15612/8581 Neighboring gene Sharpr-MPRA regulatory region 1666 Neighboring gene uncharacterized LOC105376556 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:12658187-12658688 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:12658689-12659188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3162 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:12696795-12697609 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:12697610-12698423 Neighboring gene TEAD1 intron CAGE-defined low expression enhancer 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:12701865-12702582 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:12702583-12703300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:12703301-12704018 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:12714955-12716154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12736558-12737398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3163 Neighboring gene Sharpr-MPRA regulatory region 14023 Neighboring gene Sharpr-MPRA regulatory region 9596 Neighboring gene Sharpr-MPRA regulatory region 5264 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:12788587-12789086 Neighboring gene Sharpr-MPRA regulatory region 13244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:12809225-12809732 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:12809733-12810240 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:12810874-12811512 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:12830522-12831193 Neighboring gene uncharacterized LOC107984313 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:12849868-12850506 Neighboring gene VISTA enhancer hs1314 Neighboring gene Sharpr-MPRA regulatory region 11610 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:12897776-12898276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:12902094-12903038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:12910458-12910966 Neighboring gene uncharacterized LOC124900312 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:12935478-12936342 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:12936343-12937206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3164 Neighboring gene long intergenic non-protein coding RNA 958 Neighboring gene RASSF10 divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (146 hits/1260 screens)

    Associated conditions

    Description Tests
    Helicoid peripapillary chorioretinal degeneration
    MedGen: C1862382 OMIM: 108985 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ17970

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of TEAD-YAP complex PubMed 
    part_of TEAD-YAP complex PubMed 
    located_in chromatin  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus PubMed 
    located_in nucleus  
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    transcriptional enhancer factor TEF-1
    Names
    TEA domain family member 1 (SV40 transcriptional enhancer factor)
    protein GT-IIC
    transcription factor 13
    transcriptional enhancer factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021302.1 RefSeqGene

      Range
      5000..275316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_021961.6 → NP_068780.2  transcriptional enhancer factor TEF-1

      See identical proteins and their annotated locations for NP_068780.2

      Status: REVIEWED

      Source sequence(s)
      AB209858, AC107881, BC115398, BG720371, BU172369, CA420177, CN420966, DR000961
      Consensus CDS
      CCDS7810.2
      UniProtKB/Swiss-Prot
      A4FUP2, E7EV65, P28347
      UniProtKB/TrEMBL
      H0YE88
      Related
      ENSP00000435233.2, ENST00000527636.7
      Conserved Domains (1) summary
      smart00426
      Location:30 → 97
      TEA; TEA domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      12674421..12944737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      12766927..13037265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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