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    ZNF778 zinc finger protein 778 [ Homo sapiens (human) ]

    Gene ID: 197320, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF778provided by HGNC
    Official Full Name
    zinc finger protein 778provided by HGNC
    Primary source
    HGNC:HGNC:26479
    See related
    Ensembl:ENSG00000170100 AllianceGenome:HGNC:26479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a member of the krueppel C2H2-type zinc-finger protein family, and it contains one KRAB domain and eighteen C2H2-type zinc fingers. This gene is a candidate gene for autism and variable cognitive impairment in the 16q24.3 microdeletion syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2011]
    Expression
    Ubiquitous expression in testis (RPKM 3.1), brain (RPKM 2.1) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF778 in Genome Data Viewer
    Location:
    16q24.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (89217703..89237141)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (95297944..95317628)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (89284111..89303549)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89265225-89265848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89267097-89267719 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7895 Neighboring gene solute carrier family 22 member 31 Neighboring gene Sharpr-MPRA regulatory region 4154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11397 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89284467-89284997 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:89284998-89285527 Neighboring gene ZNF778 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 2584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7896 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:89308033-89308549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7897 Neighboring gene uncharacterized LOC124903766 Neighboring gene ankyrin repeat domain containing 11 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89357571-89358417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89360111-89360956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89360957-89361803 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:89361804-89362649 Neighboring gene uncharacterized LOC105371414 Neighboring gene keratin-associated protein 5-2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of ANKRD11 and ZNF778 as candidate genes for autism and variable cognitive impairment in the novel 16q24.3 microdeletion syndrome. Willemsen MH, et al. Eur J Hum Genet, 2010 Apr. PMID 19920853, Free PMC Article
    2. ZNF768 links oncogenic RAS to cellular senescence. Villot R, et al. Nat Commun, 2021 Aug 17. PMID 34404770, Free PMC Article
    3. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    4. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    5. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF768 links oncogenic RAS to cellular senescence.
      Title: ZNF768 links oncogenic RAS to cellular senescence.
    2. ZNF778 is a candidate gene for autism and variable cognitive impairment in the novel 16q24.3 microdeletion syndrome.
      Title: Identification of ANKRD11 and ZNF778 as candidate genes for autism and variable cognitive impairment in the novel 16q24.3 microdeletion syndrome.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31875, MGC150573

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 778

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028146.1 RefSeqGene

      Range
      5001..16855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_284

    mRNA and Protein(s)

    1. NM_001201407.2 → NP_001188336.1  zinc finger protein 778 isoform 1

      See identical proteins and their annotated locations for NP_001188336.1

      Status: REVIEWED

      Source sequence(s)
      AC009113
      Consensus CDS
      CCDS73928.1
      UniProtKB/TrEMBL
      A0A0A0MSW5
      Related
      ENSP00000405289.3, ENST00000433976.7
      Conserved Domains (3) summary
      smart00349
      Location:42 → 100
      KRAB; krueppel associated box
      COG5048
      Location:380 → 747
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:591 → 611
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001378881.1 → NP_001365810.1  zinc finger protein 778 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC009113
      Consensus CDS
      CCDS73928.1
      UniProtKB/TrEMBL
      A0A0A0MSW5
      Related
      ENSP00000305203.6, ENST00000306502.6
      Conserved Domains (3) summary
      smart00349
      Location:42 → 100
      KRAB; krueppel associated box
      COG5048
      Location:380 → 747
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:591 → 611
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_182531.5 → NP_872337.2  zinc finger protein 778 isoform 2

      See identical proteins and their annotated locations for NP_872337.2

      Status: REVIEWED

      Source sequence(s)
      AC009113
      Consensus CDS
      CCDS45550.1
      UniProtKB/Swiss-Prot
      Q08AG0, Q96MU6
      Related
      ENSP00000481538.1, ENST00000620195.4
      Conserved Domains (5) summary
      smart00349
      Location:42 → 82
      KRAB; krueppel associated box
      COG5048
      Location:352 → 719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:563 → 583
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:42 → 81
      KRAB; KRAB box
      pfam13465
      Location:575 → 600
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_037705.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC009113

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      89217703..89237141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      95297944..95317628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96MU6.3 GenPept UniProtKB/Swiss-Prot:Q96MU6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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