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    CDC36 CCR4-NOT core subunit CDC36 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851389, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CDC36
    Official Full Name
    CCR4-NOT core subunit CDC36
    Primary source
    SGD:S000002324
    Locus tag
    YDL165W
    See related
    AllianceGenome:SGD:S000002324; FungiDB:YDL165W; VEuPathDB:YDL165W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DNA19; NOT2
    Summary
    Involved in several processes, including nuclear-transcribed mRNA catabolic process; positive regulation of transcription elongation by RNA polymerase II; and transcription elongation by RNA polymerase II. Located in cytoplasm and nucleus. Part of CCR4-NOT core complex. Orthologous to human CNOT2 (CCR4-NOT transcription complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CDC36 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (164290..164865)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Nrp1p Neighboring gene nucleoside-triphosphatase Neighboring gene DNA ligase (ATP) CDC9 Neighboring gene epsin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence of the yeast cell division cycle start genes CDC28, CDC36, CDC37, and CDC39, and a structural analysis of the predicted products. Ferguson J, et al. Nucleic Acids Res, 1986 Aug 26. PMID 3018676, Free PMC Article
    2. Cell-cycle mutations among the collection of Saccharomyces cerevisiae dna mutants. Evans DR, et al. FEMS Microbiol Lett, 1994 Feb 15. PMID 8150258
    3. CDC36 and CDC39 are negative elements in the signal transduction pathway of yeast. Neiman AM, et al. Cell Regul, 1990 Apr. PMID 2099190, Free PMC Article
    4. Mutations in cell division cycle genes CDC36 and CDC39 activate the Saccharomyces cerevisiae mating pheromone response pathway. de Barros Lopes M, et al. Mol Cell Biol, 1990 Jun. PMID 2111445, Free PMC Article
    5. A relationship between the yeast cell cycle genes CDC4 and CDC36 and the ets sequence of oncogenic virus E26. Peterson TA, et al. Nature, 1984 Jun 7-13. PMID 6374468

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to pheromone triggering conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CCR4-NOT core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of CCR4-NOT core complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT core subunit CDC36
    NP_010116.1
    • Component of the CCR4-NOT core complex, involved in mRNA decapping; this complex has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs through deadenylation; basal transcription factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      164290..164865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180225.1 → NP_010116.1  TPA: CCR4-NOT core subunit CDC36 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010116.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRI6, P06100
      UniProtKB/TrEMBL
      A6ZXG5, B3LH51, B5VFA7, C7GL13, C8Z6D8, G2WBZ9, N1P951
      Conserved Domains (1) summary
      COG5601
      Location:5 → 191
      CDC36; General negative regulator of transcription subunit [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06100.1

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