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    LINC01703 long intergenic non-protein coding RNA 1703 [ Homo sapiens (human) ]

    Gene ID: 105373113, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC01703provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 1703provided by HGNC
    Primary source
    HGNC:HGNC:52491
    See related
    Ensembl:ENSG00000225518 AllianceGenome:HGNC:52491
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    lncPARP1
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See LINC01703 in Genome Data Viewer
    Location:
    1q42.12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (226083575..226090289)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (225271476..225278190)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (226271276..226277990)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2639 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2641 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2643 Neighboring gene SDE2 telomere maintenance homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2644 Neighboring gene H3-3A divergent transcript Neighboring gene ReSE screen-validated silencer GRCh37_chr1:226249972-226250137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2645 Neighboring gene H3.3 histone A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:226270255-226271122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1872 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:226295966-226296160 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1873 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1875 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:226299196-226299703 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:226302781-226303585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1878 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1879 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2646 Neighboring gene Sharpr-MPRA regulatory region 5028 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8-like Neighboring gene uncharacterized LOC124904586 Neighboring gene acyl-CoA binding domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. The long noncoding RNA lncPARP1 contributes to progression of hepatocellular carcinoma through up-regulation of PARP1. Qi H, et al. Biosci Rep, 2018 Jun 29. PMID 29776974, Free PMC Article
    2. Long Noncoding RNA LINC01703 Exacerbates the Malignant Properties of Non-Small Cell Lung Cancer by Upregulating MACC1 in a MicroRNA-605-3p-Mediated Manner. Wang Z, et al. Oncol Res, 2022 Jan 31. PMID 34493358, Free PMC Article
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long Noncoding RNA LINC01703 Exacerbates the Malignant Properties of Non-Small Cell Lung Cancer by Upregulating MACC1 in a MicroRNA-605-3p-Mediated Manner.
      Title: Long Noncoding RNA LINC01703 Exacerbates the Malignant Properties of Non-Small Cell Lung Cancer by Upregulating MACC1 in a MicroRNA-605-3p-Mediated Manner.
    2. The long noncoding RNA lncPARP1 contributes to progression of hepatocellular carcinoma through up-regulation of PARP1.
      Title: The long noncoding RNA lncPARP1 contributes to progression of hepatocellular carcinoma through up-regulation of PARP1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_146920.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL512343, BC032899, DA095572
      Related
      ENST00000602806.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      226083575..226090289
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      225271476..225278190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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