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    SLC38A10 solute carrier family 38 member 10 [ Homo sapiens (human) ]

    Gene ID: 124565, updated on 10-Dec-2024

    Summary

    Official Symbol
    SLC38A10provided by HGNC
    Official Full Name
    solute carrier family 38 member 10provided by HGNC
    Primary source
    HGNC:HGNC:28237
    See related
    Ensembl:ENSG00000157637 MIM:616525; AllianceGenome:HGNC:28237
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP1744; SNAT10
    Summary
    Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to act upstream of or within bone development. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen (RPKM 17.0), placenta (RPKM 15.5) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SLC38A10 in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81244811..81295307, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82153934..82207205, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79218611..79269107, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904081 Neighboring gene TEPSIN adaptor related protein complex 4 accessory protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79212179-79212761 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79212737-79212952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12956 Neighboring gene Sharpr-MPRA regulatory region 11657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12957 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12959 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79225481-79226148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79228507-79229198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79255689-79256202 Neighboring gene Sharpr-MPRA regulatory region 13761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12961 Neighboring gene uncharacterized LOC124904082 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79273333-79273505 Neighboring gene CRISPRi-validated cis-regulatory element chr17.5937 Neighboring gene long intergenic non-protein coding RNA 482

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (33 hits/1272 screens)

    EBI GWAS Catalog

    Description
    Joint influence of small-effect genetic variants on human longevity.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Interactions

    General gene information

    Clone Names

    • FLJ35718, FLJ46399, MGC15523

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport  
    involved_in amino acid transmembrane transport  
    involved_in bone development  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    is_active_in membrane  

    General protein information

    Preferred Names
    solute carrier family 38 member 10
    Names
    Sodium-coupled neutral amino acid transporter 10
    amino acid transporter SLC38A10
    putative sodium-coupled neutral amino acid transporter 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037984.3 → NP_001033073.1  solute carrier family 38 member 10 isoform a

      See identical proteins and their annotated locations for NP_001033073.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK128330, BC014642, BI194553, BM129331, BQ642219, BU552914, CA447446, HY036951
      Consensus CDS
      CCDS42397.1
      UniProtKB/Swiss-Prot
      Q6ZRC5, Q8NA99, Q96C66, Q9HBR0
      Related
      ENSP00000363891.3, ENST00000374759.8
      Conserved Domains (4) summary
      PHA00666
      Location:582 → 739
      PHA00666; putative protease
      COG0814
      Location:14 → 397
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      pfam05466
      Location:481 → 683
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl00456
      Location:6 → 381
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. NM_138570.4 → NP_612637.1  solute carrier family 38 member 10 isoform b

      See identical proteins and their annotated locations for NP_612637.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes a 3' terminal exon that extends past a splice site used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      BC014642, BQ642219, CA416101, HY036951
      Consensus CDS
      CCDS11780.1
      UniProtKB/Swiss-Prot
      Q9HBR0
      Related
      ENSP00000288439.5, ENST00000288439.9
      Conserved Domains (3) summary
      COG0814
      Location:14 → 397
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      pfam05466
      Location:481 → 683
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl00456
      Location:6 → 381
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      81244811..81295307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257019.2 → XP_005257076.1  solute carrier family 38 member 10 isoform X2

      Conserved Domains (3) summary
      COG0814
      Location:14 → 397
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      pfam05466
      Location:481 → 683
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl00456
      Location:6 → 381
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. XM_011524289.2 → XP_011522591.1  solute carrier family 38 member 10 isoform X3

      Conserved Domains (4) summary
      PHA00666
      Location:589 → 746
      PHA00666; putative protease
      COG0814
      Location:14 → 404
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      pfam05466
      Location:488 → 690
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl00456
      Location:6 → 388
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    3. XM_011524288.2 → XP_011522590.1  solute carrier family 38 member 10 isoform X1

      Conserved Domains (3) summary
      COG0814
      Location:14 → 404
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      pfam05466
      Location:488 → 690
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl00456
      Location:6 → 388
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    4. XM_011524290.2 → XP_011522592.1  solute carrier family 38 member 10 isoform X4

      Conserved Domains (2) summary
      PRK07764
      Location:449 → 886
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cl00456
      Location:2 → 299
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      82153934..82207205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314988.1 → XP_054170963.1  solute carrier family 38 member 10 isoform X2

    2. XM_054314989.1 → XP_054170964.1  solute carrier family 38 member 10 isoform X3

    3. XM_054314987.1 → XP_054170962.1  solute carrier family 38 member 10 isoform X1

    4. XM_054314990.1 → XP_054170965.1  solute carrier family 38 member 10 isoform X4

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