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    EIF1AY eukaryotic translation initiation factor 1A Y-linked [ Homo sapiens (human) ]

    Gene ID: 9086, updated on 10-Dec-2024

    Summary

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    Official Symbol
    EIF1AYprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 1A Y-linkedprovided by HGNC
    Primary source
    HGNC:HGNC:3252
    See related
    Ensembl:ENSG00000198692 MIM:400014; AllianceGenome:HGNC:3252
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    eIF-4C
    Summary
    This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
    Expression
    Broad expression in bone marrow (RPKM 13.9), prostate (RPKM 13.1) and 20 other tissues See more
    Orthologs
    all
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    Genomic context

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    See EIF1AY in Genome Data Viewer
    Location:
    Yq11.223
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (20575776..20593154)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (21450981..21468360)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (22737662..22755040)

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene testis expressed transcript, Y-linked 10 Neighboring gene lysine demethylase 5D pseudogene 1 Neighboring gene family with sequence similarity 8, member A1 pseudogene Neighboring gene transducin beta like 1 Y-linked pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Y chromosome gene expression in the blood of male patients with ischemic stroke compared with male controls. Tian Y, et al. Gend Med, 2012 Apr. PMID 22365286, Free PMC Article
    2. H-Y antibody titers are increased in unexplained secondary recurrent miscarriage patients and associated with low male : female ratio in subsequent live births. Nielsen HS, et al. Hum Reprod, 2010 Nov. PMID 20823116, Free PMC Article
    3. The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences. Heidecker B, et al. Eur Heart J, 2010 May. PMID 20031959, Free PMC Article
    4. Expression profile of AZF genes in testicular biopsies of azoospermic men. Kleiman SE, et al. Hum Reprod, 2007 Jan. PMID 16936303
    5. Expression and significance of Rap1A in testes of azoospermic subjects. Yang B, et al. Asian J Androl, 2004 Mar. PMID 15064832

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The N-terminal tail of eIF1A mediates the interaction with eIF5 and eIF1.
      Title: The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.
    2. investigated 12 single-nucleotide polymorphisms in Y-linked neuroligin 4, transducin b-like 1, and eukaryotic translation initiation factor 1a genes, results suggest a Y chromosome effect in autism
      Title: Association of Y chromosome haplotypes with autism.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association of Y chromosome haplotypes with autism.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ45762

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 1A, Y-chromosomal
    Names
    eIF1A Y isoform
    eukaryotic translation initiation factor 1A, Y chromosome
    eukaryotic translation initiation factor 4C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278612.2 → NP_001265541.1  eukaryotic translation initiation factor 1A, Y-chromosomal isoform 2

      See identical proteins and their annotated locations for NP_001265541.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC007678, AF000987, BG499107, DQ786267
      Consensus CDS
      CCDS65368.1
      UniProtKB/TrEMBL
      A6NJH9
      Related
      ENSP00000372222.3, ENST00000382772.3
      Conserved Domains (1) summary
      cl09927
      Location:1 → 114
      S1_like; Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. Both domains ...

    2. NM_004681.4 → NP_004672.2  eukaryotic translation initiation factor 1A, Y-chromosomal isoform 1

      See identical proteins and their annotated locations for NP_004672.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC007678, AF000987, BC005248, BG499107
      Consensus CDS
      CCDS14795.1
      UniProtKB/Swiss-Prot
      O14602, Q9BS77
      Related
      ENSP00000354722.2, ENST00000361365.7
      Conserved Domains (1) summary
      PTZ00329
      Location:1 → 131
      PTZ00329; eukaryotic translation initiation factor 1A; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

      Range
      20575776..20593154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060948.1 Alternate T2T-CHM13v2.0

      Range
      21450981..21468360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14602.4 GenPept UniProtKB/Swiss-Prot:O14602

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools