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    ADARB1 adenosine deaminase RNA specific B1 [ Homo sapiens (human) ]

    Gene ID: 104, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ADARB1provided by HGNC
    Official Full Name
    adenosine deaminase RNA specific B1provided by HGNC
    Primary source
    HGNC:HGNC:226
    See related
    Ensembl:ENSG00000197381 MIM:601218; AllianceGenome:HGNC:226
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RED1; ADAR2; DRABA2; DRADA2; NEDHYMS
    Summary
    This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lung (RPKM 5.2), urinary bladder (RPKM 3.4) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ADARB1 in Genome Data Viewer
    Location:
    21q22.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (45074578..45226563)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (43436861..43590594)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (46494493..46646478)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46422723-46423264 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr21:46431794-46432993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46436709-46437209 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46438875-46439748 Neighboring gene P38 inhibited cutaneous squamous cell carcinoma associated lincRNA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46448329-46448828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46451141-46451808 Neighboring gene uncharacterized LOC105372836 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr21:46470000-46471199 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46471769-46472400 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46484683-46485516 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46513297-46513797 Neighboring gene signal sequence receptor subunit 4 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18586 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46553428-46553928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46553929-46554429 Neighboring gene Sharpr-MPRA regulatory region 4412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46569001-46569596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46571268-46572124 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46580749-46581394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46622742-46623359 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46626875-46627374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46640206-46640772 Neighboring gene U2 spliceosomal RNA Neighboring gene long intergenic non-protein coding RNA 334 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46675963-46676514 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr21:46699476-46700675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13401 Neighboring gene protein O-fucosyltransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Function of low ADARB1 expression in lung adenocarcinoma. Wang X, et al. PLoS One, 2019. PMID 31491024, Free PMC Article
    2. Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition. Thuy-Boun AS, et al. Nucleic Acids Res, 2020 Aug 20. PMID 32597966, Free PMC Article
    3. Evidence for auto-inhibition by the N terminus of hADAR2 and activation by dsRNA binding. Macbeth MR, et al. RNA, 2004 Oct. PMID 15383678, Free PMC Article
    4. Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing. Macbeth MR, et al. Science, 2005 Sep 2. PMID 16141067, Free PMC Article
    5. Bi-allelic ADARB1 Variants Associated with Microcephaly, Intellectual Disability, and Seizures. Tan TY, et al. Am J Hum Genet, 2020 Apr 2. PMID 32220291, Free PMC Article

    See all (121) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Orchestration of a blood-derived and ADARB1-centred network in Alzheimer's and Parkinson's disease.
      Title: Orchestration of a blood-derived and ADARB1-centred network in Alzheimer's and Parkinson's disease.
    2. Core-binding factor fusion downregulation of ADAR2 RNA editing contributes to AML leukemogenesis.
      Title: Core-binding factor fusion downregulation of ADAR2 RNA editing contributes to AML leukemogenesis.
    3. Targeting the androgen receptor to enhance NK cell killing efficacy in bladder cancer by modulating ADAR2/circ_0001005/PD-L1 signaling.
      Title: Targeting the androgen receptor to enhance NK cell killing efficacy in bladder cancer by modulating ADAR2/circ_0001005/PD-L1 signaling.
    4. ADAR2 enzymes: efficient site-specific RNA editors with gene therapy aspirations.
      Title: ADAR2 enzymes: efficient site-specific RNA editors with gene therapy aspirations.
    5. Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity.
      Title: Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity.
    6. Developing PspCas13b-based enhanced RESCUE system, eRESCUE, with efficient RNA base editing.
      Title: Developing PspCas13b-based enhanced RESCUE system, eRESCUE, with efficient RNA base editing.
    7. Biallelic variants in ADARB1, encoding a dsRNA-specific adenosine deaminase, cause a severe developmental and epileptic encephalopathy.
      Title: Biallelic variants in ADARB1, encoding a dsRNA-specific adenosine deaminase, cause a severe developmental and epileptic encephalopathy.
    8. Short-Chain Guide RNA for Site-Directed A-to-I RNA Editing.
      Title: Short-Chain Guide RNA for Site-Directed A-to-I RNA Editing.
    9. ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair.
      Title: ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair.
    10. What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs.
      Title: What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs.
    Submit: New GeneRIF Correction See all GeneRIFs (72)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Neurodevelopmental disorder with hypotonia, microcephaly, and seizures
    MedGen: C5394312 OMIM: 618862 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    Framingham Heart Study genome-wide association: results for pulmonary function measures.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 inhibits adenosine deaminase (ADA) binding to CD26 (dipeptidyl-peptidase 4) in both CD4+ and CD4- cells; this effect requires the interaction of gp120 with CD4 or CXCR4 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables RNA binding HDA PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA adenosine deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mRNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tRNA-specific adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenosine to inosine editing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenosine to inosine editing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in base conversion or substitution editing IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in base conversion or substitution editing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in facial nerve morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hypoglossal nerve morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innervation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in motor behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in motor neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in muscle tissue morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuromuscular process controlling posture IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuromuscular synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spinal cord ventral commissure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    double-stranded RNA-specific editase 1
    Names
    RNA editing deaminase 1
    RNA-editing enzyme 1
    adenosine deaminase, RNA-specific, B1 (homolog of rat RED1)
    dsRNA adenosine deaminase DRADA2
    NP_001103.1
    NP_001153702.1
    NP_001333616.1
    NP_001333617.1
    NP_001397651.1
    NP_056648.1
    NP_056649.1
    XP_016883733.1
    XP_016883740.1
    XP_016883742.1
    XP_047296616.1
    XP_047296617.1
    XP_047296618.1
    XP_047296619.1
    XP_047296620.1
    XP_047296621.1
    XP_047296622.1
    XP_047296623.1
    XP_054180277.1
    XP_054180278.1
    XP_054180279.1
    XP_054180280.1
    XP_054180281.1
    XP_054180282.1
    XP_054180283.1
    XP_054180284.1
    XP_054180285.1
    XP_054180286.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052015.1 RefSeqGene

      Range
      5003..156983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001112.4 → NP_001103.1  double-stranded RNA-specific editase 1 isoform 1

      See identical proteins and their annotated locations for NP_001103.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as ADAR2a-L1 or DRADA2a, lacks the ALU cassette insert and contains the long C-terminal region, as compared to variant 2. The resulting isoform (1), also known as hRED1-Short, lacks an internal segment, compared to isoform 2.
      Source sequence(s)
      AB194370, BC030663, BU726292
      Consensus CDS
      CCDS33590.1
      UniProtKB/TrEMBL
      Q86XN4
      Related
      ENSP00000015877.6, ENST00000348831.9
      Conserved Domains (2) summary
      smart00552
      Location:322 → 698
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd00048
      Location:79 → 142
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

    2. NM_001160230.2 → NP_001153702.1  double-stranded RNA-specific editase 1 isoform 7

      See identical proteins and their annotated locations for NP_001153702.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), also known as ADAR2d, lacks the ALU cassette insert and an alternate segment in the 3' coding region, compared to variant 2. The resulting isoform (7) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 2, and contains the short C-terminal region. Variants 7 and 10 encode the same isoform.
      Source sequence(s)
      AB194373, BC030663, BU726292
      UniProtKB/TrEMBL
      Q86XN4
      Conserved Domains (2) summary
      smart00552
      Location:322 → 672
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd00048
      Location:79 → 142
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

    3. NM_001346687.2 → NP_001333616.1  double-stranded RNA-specific editase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL133499, BU726292, BX322560, FJ169506
      Consensus CDS
      CCDS93105.1
      UniProtKB/TrEMBL
      A0A994J4V7, O43263
      Related
      ENSP00000516123.1, ENST00000705393.1

    4. NM_001346688.2 → NP_001333617.1  double-stranded RNA-specific editase 1 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: Variants 7 and 10 encode the same isoform (7).
      Source sequence(s)
      AL133499, AP001579, BU726292, BX322560
      UniProtKB/TrEMBL
      Q86XN4

    5. NM_001410722.1 → NP_001397651.1  double-stranded RNA-specific editase 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL133499, BX322560
      Consensus CDS
      CCDS93106.1
      UniProtKB/TrEMBL
      A0A994J7T5, Q86XN4
      Related
      ENSP00000516122.1, ENST00000705392.1

    6. NM_015833.4 → NP_056648.1  double-stranded RNA-specific editase 1 isoform 2

      See identical proteins and their annotated locations for NP_056648.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as DRADA2b, represents the longest transcript, which includes the ALU cassette insert and the long C-terminal region. It encodes the longest isoform (2), also known as hRED1-Long.
      Source sequence(s)
      AB194370, BC030663, BU726292, U76421
      Consensus CDS
      CCDS33589.1
      UniProtKB/Swiss-Prot
      A6NFK8, A6NJ84, C3TTQ1, C3TTQ2, C9JUP4, G5E9B4, O00395, O00465, O00691, O00692, P78555, P78563, Q4AE77, Q4AE79, Q6P0M9, Q8NFA1, Q8NFD1
      UniProtKB/TrEMBL
      O43263
      Related
      ENSP00000353920.3, ENST00000360697.4
      Conserved Domains (3) summary
      smart00552
      Location:322 → 738
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd19895
      Location:75 → 146
      DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
      cd19898
      Location:232 → 301
      DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

    7. NM_015834.4 → NP_056649.1  double-stranded RNA-specific editase 1 isoform 3

      See identical proteins and their annotated locations for NP_056649.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as DRADA2c, lacks an alternate segment in the 3' coding region, compared to variant 2. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 2, and contains the ALU cassette insert and the short C-terminal region.
      Source sequence(s)
      BC030663, BU726292, U76422
      Consensus CDS
      CCDS42970.1
      UniProtKB/TrEMBL
      O43263
      Related
      ENSP00000374513.4, ENST00000389863.8
      Conserved Domains (3) summary
      smart00552
      Location:322 → 712
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd00048
      Location:79 → 142
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam13900
      Location:471 → 496
      GVQW; Putative domain of unknown function

    RNA

    1. NR_027672.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), also known as ADAR2g, lacks the second coding exon, the ALU cassette insert, and a segment of the 3' UTR, compared to transcript variant 2. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD), and no protein is expressed by in vitro translation according to Kawahara et al. (PMID: 16297572).
      Source sequence(s)
      AB194369, BC030663, BU726292

    2. NR_027673.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an additional 5' exon, lacks the ALU cassette, and lacks a segment of the 3' UTR, compared to variant 2. This variant is represented as non-coding because it contains an uORF that is predicted to inhibit translation of the primary ORF. The transcript is also a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB194370, AY135659, BC030663, BU726292

    3. NR_027674.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), also known as ADAR2a-L2, lacks the ALU cassette insert and a segment of the 3' UTR, compared to variant 2. This variant is represented as non-coding because the additional splicing in the 3' UTR renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB194371, BC030663, BU726292

    4. NR_073200.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an internal portion of the last exon compared to variant 2. This variant is represented as non-coding because the additional splicing in the 3' UTR renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC030663, BU726292, U76421

    5. NR_144483.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AB194372, BC030663, BU726292

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      45074578..45226563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017028251.2 → XP_016883740.1  double-stranded RNA-specific editase 1 isoform X5

      UniProtKB/Swiss-Prot
      A6NFK8, A6NJ84, C3TTQ1, C3TTQ2, C9JUP4, G5E9B4, O00395, O00465, O00691, O00692, P78555, P78563, Q4AE77, Q4AE79, Q6P0M9, Q8NFA1, Q8NFD1
      UniProtKB/TrEMBL
      O43263
      Related
      ENSP00000387480.2, ENST00000449478.2
      Conserved Domains (3) summary
      smart00552
      Location:322 → 738
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd19895
      Location:75 → 146
      DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
      cd19898
      Location:232 → 301
      DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

    2. XM_047440660.1 → XP_047296616.1  double-stranded RNA-specific editase 1 isoform X1

      UniProtKB/TrEMBL
      O43263

    3. XM_047440661.1 → XP_047296617.1  double-stranded RNA-specific editase 1 isoform X1

      UniProtKB/TrEMBL
      O43263

    4. XM_047440665.1 → XP_047296621.1  double-stranded RNA-specific editase 1 isoform X5

      UniProtKB/Swiss-Prot
      A6NFK8, A6NJ84, C3TTQ1, C3TTQ2, C9JUP4, G5E9B4, O00395, O00465, O00691, O00692, P78555, P78563, Q4AE77, Q4AE79, Q6P0M9, Q8NFA1, Q8NFD1
      UniProtKB/TrEMBL
      O43263

    5. XM_047440667.1 → XP_047296623.1  double-stranded RNA-specific editase 1 isoform X8

      UniProtKB/TrEMBL
      Q86XN4

    6. XM_047440662.1 → XP_047296618.1  double-stranded RNA-specific editase 1 isoform X2

      UniProtKB/TrEMBL
      O43263

    7. XM_047440663.1 → XP_047296619.1  double-stranded RNA-specific editase 1 isoform X4

      UniProtKB/TrEMBL
      O43263

    8. XM_047440666.1 → XP_047296622.1  double-stranded RNA-specific editase 1 isoform X7

      UniProtKB/TrEMBL
      O43263

    9. XM_047440664.1 → XP_047296620.1  double-stranded RNA-specific editase 1 isoform X5

      UniProtKB/Swiss-Prot
      A6NFK8, A6NJ84, C3TTQ1, C3TTQ2, C9JUP4, G5E9B4, O00395, O00465, O00691, O00692, P78555, P78563, Q4AE77, Q4AE79, Q6P0M9, Q8NFA1, Q8NFD1
      UniProtKB/TrEMBL
      O43263

    10. XM_017028244.3 → XP_016883733.1  double-stranded RNA-specific editase 1 isoform X3

      UniProtKB/TrEMBL
      O43263

    11. XM_017028253.3 → XP_016883742.1  double-stranded RNA-specific editase 1 isoform X6

      UniProtKB/TrEMBL
      Q86XN4

    RNA

    1. XR_001754787.3 RNA Sequence

    2. XR_007067777.1 RNA Sequence

    3. XR_007067778.1 RNA Sequence

    4. XR_001754792.3 RNA Sequence

    5. XR_001754791.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      43436861..43590594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324308.1 → XP_054180283.1  double-stranded RNA-specific editase 1 isoform X5

      UniProtKB/Swiss-Prot
      A6NFK8, A6NJ84, C3TTQ1, C3TTQ2, C9JUP4, G5E9B4, O00395, O00465, O00691, O00692, P78555, P78563, Q4AE77, Q4AE79, Q6P0M9, Q8NFA1, Q8NFD1
      UniProtKB/TrEMBL
      O43263

    2. XM_054324302.1 → XP_054180277.1  double-stranded RNA-specific editase 1 isoform X1

      UniProtKB/TrEMBL
      O43263

    3. XM_054324307.1 → XP_054180282.1  double-stranded RNA-specific editase 1 isoform X5

      UniProtKB/Swiss-Prot
      A6NFK8, A6NJ84, C3TTQ1, C3TTQ2, C9JUP4, G5E9B4, O00395, O00465, O00691, O00692, P78555, P78563, Q4AE77, Q4AE79, Q6P0M9, Q8NFA1, Q8NFD1
      UniProtKB/TrEMBL
      O43263

    4. XM_054324311.1 → XP_054180286.1  double-stranded RNA-specific editase 1 isoform X8

      UniProtKB/TrEMBL
      Q86XN4

    5. XM_054324303.1 → XP_054180278.1  double-stranded RNA-specific editase 1 isoform X2

      UniProtKB/TrEMBL
      O43263

    6. XM_054324305.1 → XP_054180280.1  double-stranded RNA-specific editase 1 isoform X4

      UniProtKB/TrEMBL
      O43263

    7. XM_054324310.1 → XP_054180285.1  double-stranded RNA-specific editase 1 isoform X7

      UniProtKB/TrEMBL
      O43263

    8. XM_054324306.1 → XP_054180281.1  double-stranded RNA-specific editase 1 isoform X5

      UniProtKB/Swiss-Prot
      A6NFK8, A6NJ84, C3TTQ1, C3TTQ2, C9JUP4, G5E9B4, O00395, O00465, O00691, O00692, P78555, P78563, Q4AE77, Q4AE79, Q6P0M9, Q8NFA1, Q8NFD1
      UniProtKB/TrEMBL
      O43263

    9. XM_054324304.1 → XP_054180279.1  double-stranded RNA-specific editase 1 isoform X3

      UniProtKB/TrEMBL
      O43263

    10. XM_054324309.1 → XP_054180284.1  double-stranded RNA-specific editase 1 isoform X6

      UniProtKB/TrEMBL
      Q86XN4

    RNA

    1. XR_008485323.1 RNA Sequence

    2. XR_008485324.1 RNA Sequence

    3. XR_008485325.1 RNA Sequence

    4. XR_008485326.1 RNA Sequence

    5. XR_008485327.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033049.1: Suppressed sequence

      Description
      NM_001033049.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate, and the annotated CDS is unlikely to be translated because of an upstream ORF.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P78563.1 GenPept UniProtKB/Swiss-Prot:P78563

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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