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    FETUB fetuin B [ Homo sapiens (human) ]

    Gene ID: 26998, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FETUBprovided by HGNC
    Official Full Name
    fetuin Bprovided by HGNC
    Primary source
    HGNC:HGNC:3658
    See related
    Ensembl:ENSG00000090512 MIM:605954; AllianceGenome:HGNC:3658
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    16G2; Gugu; IRL685
    Summary
    The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward liver (RPKM 42.7) See more
    Orthologs
    mouse all
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    Genomic context

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    See FETUB in Genome Data Viewer
    Location:
    3q27.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (186635969..186653141)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (189451683..189468852)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (186353758..186370930)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9080 Neighboring gene PET100 pseudogene 1 Neighboring gene alpha 2-HS glycoprotein Neighboring gene HRG and FETUB antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:186375416-186375935 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr3:186380938-186381618 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:186386725-186387924 Neighboring gene histidine rich glycoprotein Neighboring gene HRG pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. The serum protein fetuin-B is involved in the development of acute myocardial infarction. Jung SH, et al. Clin Sci (Lond), 2015 Jul. PMID 25671698
    2. Increased serum levels of fetuin B in patients with coronary artery disease. Zhu K, et al. Endocrine, 2017 Oct. PMID 28822077
    3. Serum fetuin B level increased in subjects of nonalcoholic fatty liver disease: a case-control study. Zhu J, et al. Endocrine, 2017 Apr. PMID 27628583
    4. Serum concentrations of fetuin B in lipodystrophic patients. Miehle K, et al. Cytokine, 2018 Jun. PMID 29153939
    5. Serum fetuin-B is positively associated with intrahepatic triglyceride content and increases the risk of insulin resistance in obese Chinese adults: A cross-sectional study. Wang D, et al. J Diabetes, 2018 Jul. PMID 29194974

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fetuin-B Overexpression Promotes Inflammation in Diabetic Retinopathy Through Activating Microglia and the NF-kappaB Signaling Pathway.
      Title: Fetuin-B Overexpression Promotes Inflammation in Diabetic Retinopathy Through Activating Microglia and the NF-κB Signaling Pathway.
    2. Hepatokine Fetuin B expression is regulated by leptin-STAT3 signalling and associated with leptin in obesity.
      Title: Hepatokine Fetuin B expression is regulated by leptin-STAT3 signalling and associated with leptin in obesity.
    3. Association of Fetuin-B with Subclinical Atherosclerosis in Obese Chinese Adults.
      Title: Association of Fetuin-B with Subclinical Atherosclerosis in Obese Chinese Adults.
    4. Fetuin-B regulates vascular plaque rupture via TGF-beta receptor-mediated Smad pathway in vascular smooth muscle cells.
      Title: Fetuin-B regulates vascular plaque rupture via TGF-β receptor-mediated Smad pathway in vascular smooth muscle cells.
    5. Fetuin B overexpression suppresses proliferation, migration, and invasion in prostate cancer by inhibiting the PI3K/AKT signaling pathway.
      Title: Fetuin B overexpression suppresses proliferation, migration, and invasion in prostate cancer by inhibiting the PI3K/AKT signaling pathway.
    6. The C-terminal region of human plasma fetuin-B is dispensable for the raised-elephant-trunk mechanism of inhibition of astacin metallopeptidases.
      Title: The C-terminal region of human plasma fetuin-B is dispensable for the raised-elephant-trunk mechanism of inhibition of astacin metallopeptidases.
    7. Serum fetuin-B level is an independent marker for nonalcoholic fatty liver disease in patients with type 2 diabetes.
      Title: Serum fetuin-B level is an independent marker for nonalcoholic fatty liver disease in patients with type 2 diabetes.
    8. Serum fetuin-B level is correlated with fertilization rate in conventional IVF and it may be used as a predictive marker of fertilization in IVF treatment.
      Title: Serum and follicular fluid fetuin-B levels are correlated with fertilization rates in conventional IVF cycles.
    9. High Fetuin B expression is associated with vitamin D deficiency and pediatric obesity.
      Title: Fetuin B links vitamin D deficiency and pediatric obesity: Direct negative regulation by vitamin D.
    10. Fetuin-B links nonalcoholic fatty liver disease (NAFLD) to type 2 diabetes (T2D) via inducing insulin resistance, and NAFLD contributes to the pathogenesis of T2D via multiple mechanisms.
      Title: Fetuin-B links nonalcoholic fatty liver disease to type 2 diabetes via inducing insulin resistance: Association and path analyses.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 binds to the natural glycoprotein fetuin PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in binding of sperm to zona pellucida ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in single fertilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fetuin-B
    Names
    fetuin-like protein IRL685

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308077.4 → NP_001295006.1  fetuin-B isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC068631
      Consensus CDS
      CCDS82884.1
      UniProtKB/TrEMBL
      Q5J875
      Related
      ENSP00000371571.3, ENST00000382136.3
      Conserved Domains (1) summary
      smart00043
      Location:113 → 218
      CY; Cystatin-like domain

    2. NM_001308079.4 → NP_001295008.1  fetuin-B isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC068631
      Consensus CDS
      CCDS77871.1
      UniProtKB/TrEMBL
      E9PG08, Q5J875
      Related
      ENSP00000371569.3, ENST00000382134.7
      Conserved Domains (1) summary
      smart00043
      Location:85 → 190
      CY; Cystatin-like domain

    3. NM_001375587.2 → NP_001362516.1  fetuin-B isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC068631
      Consensus CDS
      CCDS3279.1
      UniProtKB/Swiss-Prot
      B2RCW6, E9PG06, Q1RMZ0, Q5J876, Q6DK58, Q6GRB6, Q9UGM5, Q9Y6Z0
      UniProtKB/TrEMBL
      Q5J875
      Related
      ENSP00000404288.1, ENST00000450521.5
      Conserved Domains (1) summary
      smart00043
      Location:150 → 255
      CY; Cystatin-like domain

    4. NM_001375588.2 → NP_001362517.1  fetuin-B isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC068631
      Conserved Domains (1) summary
      smart00043
      Location:45 → 150
      CY; Cystatin-like domain

    5. NM_001375589.2 → NP_001362518.1  fetuin-B isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC068631
      UniProtKB/TrEMBL
      B7Z8T3
      Conserved Domains (1) summary
      smart00043
      Location:2 → 107
      CY; Cystatin-like domain

    6. NM_001375590.2 → NP_001362519.1  fetuin-B isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC068631
      UniProtKB/TrEMBL
      B7Z8T3
      Conserved Domains (1) summary
      smart00043
      Location:2 → 107
      CY; Cystatin-like domain

    7. NM_001375591.2 → NP_001362520.1  fetuin-B isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC068631
      UniProtKB/TrEMBL
      B7Z8T3
      Conserved Domains (1) summary
      smart00043
      Location:2 → 107
      CY; Cystatin-like domain

    8. NM_001375592.2 → NP_001362521.1  fetuin-B isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC068631
      UniProtKB/TrEMBL
      B7Z8T3
      Conserved Domains (1) summary
      smart00043
      Location:2 → 107
      CY; Cystatin-like domain

    9. NM_014375.3 → NP_055190.2  fetuin-B isoform 1 precursor

      See identical proteins and their annotated locations for NP_055190.2

      Status: REVIEWED

      Source sequence(s)
      AC068631, AJ242928, BC069670, BX115543
      Consensus CDS
      CCDS3279.1
      UniProtKB/Swiss-Prot
      B2RCW6, E9PG06, Q1RMZ0, Q5J876, Q6DK58, Q6GRB6, Q9UGM5, Q9Y6Z0
      UniProtKB/TrEMBL
      Q5J875
      Related
      ENSP00000265029.3, ENST00000265029.8
      Conserved Domains (1) summary
      smart00043
      Location:150 → 255
      CY; Cystatin-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      186635969..186653141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      189451683..189468852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UGM5.2 GenPept UniProtKB/Swiss-Prot:Q9UGM5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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