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    METTL9 methyltransferase 9, His-X-His N1(pi)-histidine [ Homo sapiens (human) ]

    Gene ID: 51108, updated on 27-Dec-2024

    Summary

    Official Symbol
    METTL9provided by HGNC
    Official Full Name
    methyltransferase 9, His-X-His N1(pi)-histidineprovided by HGNC
    Primary source
    HGNC:HGNC:24586
    See related
    Ensembl:ENSG00000197006 MIM:609388; AllianceGenome:HGNC:24586
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DREV; PAP1; DREV1; CGI-81; hMETTL9
    Summary
    Enables protein-L-histidine N-pros-methyltransferase activity. Predicted to be involved in methylation. Is active in endoplasmic reticulum and mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney (RPKM 38.8), adrenal (RPKM 37.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See METTL9 in Genome Data Viewer
    Location:
    16p12.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (21597208..21657471)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (22559463..22619737, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (21608529..21668792)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr16:21529065-21529231 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21531393-21532126 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21532127-21532859 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21532860-21533594 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21535062-21535794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21536490-21537300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21537301-21538111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:21538112-21538922 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43111 Neighboring gene solute carrier family 7 member 5 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:21549325-21549826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:21549827-21550326 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:21552333-21553071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10557 Neighboring gene carbonic anhydrase 5A pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:21561118-21561618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:21562361-21562862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:21565604-21566414 Neighboring gene uncharacterized LOC101927814 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7257 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:21611613-21612177 Neighboring gene uncharacterized LOC124903663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10558 Neighboring gene RNA, U6 small nuclear 1005, pseudogene Neighboring gene RNA, U6 small nuclear 196, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10559 Neighboring gene immunoglobulin superfamily member 6 Neighboring gene otoancorin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10560 Neighboring gene uncharacterized LOC105371126 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:21801669-21802169

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • FLJ21912

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in methylation  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum PubMed 
    located_in mitochondrion PubMed 
    is_active_in mitochondrion PubMed 

    General protein information

    Preferred Names
    protein-L-histidine N-pros-methyltransferase
    Names
    CTB-31N19.3
    DORA reverse strand protein 1
    methyltransferase 9, His-X-His N1-histidine
    methyltransferase like 9
    methyltransferase-like protein 9
    p53 activated protein 1
    NP_001070648.1
    NP_001275588.1
    NP_001275589.1
    NP_057109.3
    XP_054188124.1
    XP_054236409.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077180.3 → NP_001070648.1  protein-L-histidine N-pros-methyltransferase isoform 2 precursor

      See identical proteins and their annotated locations for NP_001070648.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AJ278578, BC000195
      Consensus CDS
      CCDS45440.1
      UniProtKB/TrEMBL
      B2R7Q6
      Related
      ENSP00000379335.4, ENST00000396014.8
      Conserved Domains (1) summary
      pfam05219
      Location:56 → 316
      DREV; DREV methyltransferase
    2. NM_001288659.2 → NP_001275588.1  protein-L-histidine N-pros-methyltransferase isoform 3

      See identical proteins and their annotated locations for NP_001275588.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC005632, BC000195, BG183771
      UniProtKB/TrEMBL
      Q8TD49
      Related
      ENSP00000454733.1, ENST00000567404.5
      Conserved Domains (1) summary
      pfam05219
      Location:16 → 277
      DREV; DREV methyltransferase
    3. NM_001288660.2 → NP_001275589.1  protein-L-histidine N-pros-methyltransferase isoform 4

      See identical proteins and their annotated locations for NP_001275589.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, uses an alternate in-frame splice site in the 3' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC005632, AJ278578, BC000195, BG183771
      UniProtKB/TrEMBL
      Q8TD49
      Conserved Domains (1) summary
      pfam05219
      Location:16 → 276
      DREV; DREV methyltransferase
    4. NM_016025.5 → NP_057109.3  protein-L-histidine N-pros-methyltransferase isoform 1 precursor

      See identical proteins and their annotated locations for NP_057109.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC000195, CF146931
      Consensus CDS
      CCDS10598.2
      UniProtKB/Swiss-Prot
      Q8NBT8, Q9BWJ7, Q9H1A2, Q9H1A3, Q9Y390
      UniProtKB/TrEMBL
      B2R7Q6
      Related
      ENSP00000350874.3, ENST00000358154.8
      Conserved Domains (1) summary
      pfam05219
      Location:56 → 317
      DREV; DREV methyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      21597208..21657471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_017852933.1 Reference GRCh38.p14 PATCHES

      Range
      1447357..1507609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332149.1 → XP_054188124.1  protein-L-histidine N-pros-methyltransferase isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      22559463..22619737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380434.1 → XP_054236409.1  protein-L-histidine N-pros-methyltransferase isoform X2

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