ZBTB32 zinc finger and BTB domain containing 32 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZBTB32provided by HGNC
Official Full Name: zinc finger and BTB domain containing 32provided by HGNC
Primary source: HGNC:HGNC:16763
See related: Ensembl:ENSG00000011590 MIM:605859; AllianceGenome:HGNC:16763
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Rog; FAXF; FAZF; TZFP; mynn; ZNF538
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis (RPKM 13.5), lymph node (RPKM 1.5) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (35704558..35717038)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (38249885..38262352)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (36195460..36207940)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZBTB32 is a novel negative regulator of antibody recall responses.
Title: ZBTB32 Restricts the Duration of Memory B Cell Recall Responses.
confirmed that the promyelocytic leukemia zinc finger (PLZF) BTB dimer is strand exchanged in solution, while the FAZF BTB dimer is not
Title: Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1.
Here, it was shown that human endogenous retrovirus Rec can form a trimeric complex with TZFP and AR, and can relieve the TZFP-mediated repression of AR-induced transactivation.
Title: Human endogenous retrovirus protein Rec interacts with the testicular zinc-finger protein and androgen receptor.
TZFP is identified as a novel BMP2-induced transcription factor during osteoblastic differentiation.
Title: Identification of FAZF as a novel BMP2-induced transcription factor during osteoblastic differentiation.
results suggest an essential role for FAZF during the proliferative stages of primitive hematopoietic progenitors, possibly acting in concert with (a subset of) the Fanconi anemia proteins
Title: The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific.
can interact with GATA-2 and can modify GATA-2 transactivation capacity
Title: Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	ISA Inferred from Sequence Alignment more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 32

Names: FANCC-interacting protein; fanconi anemia zinc finger protein; myoneurin; repressor of GATA; testis zinc finger protein; zinc finger protein 538

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001316902.2 → NP_001303831.1 zinc finger and BTB domain-containing protein 32 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AF130255, HY027719, HY039545

UniProtKB/Swiss-Prot

Q9Y2Y4

Conserved Domains (2) summary

sd00017
Location:98 → 118

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:111 → 132

zf-H2C2_2; Zinc-finger double domain
NM_001316903.2 → NP_001303832.1 zinc finger and BTB domain-containing protein 32 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice junction and lacks an alternate exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AF130255, BX095236, HY027719

UniProtKB/Swiss-Prot

Q9Y2Y4

Conserved Domains (2) summary

COG5048
Location:41 → 91

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:43 → 63

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_014383.3 → NP_055198.1 zinc finger and BTB domain-containing protein 32 isoform 1

See identical proteins and their annotated locations for NP_055198.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AF130255, HY027719

Consensus CDS

CCDS12471.1

UniProtKB/Swiss-Prot

Q8WVP2, Q9Y2Y4

Related

ENSP00000376035.1, ENST00000392197.7

Conserved Domains (3) summary

COG5048
Location:373 → 423

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:375 → 395

ZF_C2H2; C2H2 Zn finger [structural motif]

cl02518
Location:23 → 109

BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

35704558..35717038

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017026591.2 → XP_016882080.1 zinc finger and BTB domain-containing protein 32 isoform X1

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

38249885..38262352

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054320532.1 → XP_054176507.1 zinc finger and BTB domain-containing protein 32 isoform X3

UniProtKB/Swiss-Prot

Q8WVP2, Q9Y2Y4
XM_054320531.1 → XP_054176506.1 zinc finger and BTB domain-containing protein 32 isoform X2
XM_054320535.1 → XP_054176510.1 zinc finger and BTB domain-containing protein 32 isoform X6

UniProtKB/TrEMBL

A0A0C4DGF1, A0A0S2Z5S3
XM_054320536.1 → XP_054176511.1 zinc finger and BTB domain-containing protein 32 isoform X1
XM_054320533.1 → XP_054176508.1 zinc finger and BTB domain-containing protein 32 isoform X4
XM_054320534.1 → XP_054176509.1 zinc finger and BTB domain-containing protein 32 isoform X5

UniProtKB/TrEMBL

A0A0S2Z5S3
XM_054320537.1 → XP_054176512.1 zinc finger and BTB domain-containing protein 32 isoform X7