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    GPR88 G protein-coupled receptor 88 [ Homo sapiens (human) ]

    Gene ID: 54112, updated on 10-Dec-2024

    Summary

    Official Symbol
    GPR88provided by HGNC
    Official Full Name
    G protein-coupled receptor 88provided by HGNC
    Primary source
    HGNC:HGNC:4539
    See related
    Ensembl:ENSG00000181656 MIM:607468; AllianceGenome:HGNC:4539
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STRG; COCPMR
    Summary
    The protein encoded by this gene is a G protein-coupled receptor found almost exclusively in the striatum, a brain structure that controls motor function and cognition. Defects in this gene have been associated with chorea, speech delay, and learning difficulties, as well as some neuropsychiatric disorders. [provided by RefSeq, Mar 2017]
    Expression
    Biased expression in spleen (RPKM 5.3), liver (RPKM 2.4) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GPR88 in Genome Data Viewer
    Location:
    1p21.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (100538139..100542021)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (100386520..100390416)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (101003695..101007577)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cell division cycle 14A Neighboring gene uncharacterized LOC105379827 Neighboring gene BCAS2 pseudogene 2 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:100927704-100928325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1383 Neighboring gene Sharpr-MPRA regulatory region 2368 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:101004119-101004968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:101004969-101005817 Neighboring gene HNF4 motif-containing MPRA enhancer 127 Neighboring gene ribosomal protein L7a pseudogene 17 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:101088137-101088435 Neighboring gene long intergenic non-protein coding RNA 1349

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled photoreceptor activity  
    enables beta2-adrenergic receptor activity PubMed 
    enables cytoskeletal motor activity  
    Component Evidence Code Pubs
    located_in ciliary membrane PubMed 
    located_in cilium PubMed 
    located_in cytoplasm  
    located_in nucleus  
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    G protein-coupled receptor 88
    Names
    probable G-protein coupled receptor 88
    striatum-specific G-protein coupled receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053134.1 RefSeqGene

      Range
      4968..8850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_022049.3NP_071332.2  G protein-coupled receptor 88

      See identical proteins and their annotated locations for NP_071332.2

      Status: REVIEWED

      Source sequence(s)
      AC099670, BC036775
      Consensus CDS
      CCDS772.1
      UniProtKB/Swiss-Prot
      Q29S24, Q6VN48, Q9GZN0
      Related
      ENSP00000314223.4, ENST00000315033.5
      Conserved Domains (1) summary
      cd15211
      Location:33347
      7tmA_GPR88-like; G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      100538139..100542021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      100386520..100390416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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