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    CHST14 carbohydrate sulfotransferase 14 [ Homo sapiens (human) ]

    Gene ID: 113189, updated on 10-Dec-2024

    Summary

    Official Symbol
    CHST14provided by HGNC
    Official Full Name
    carbohydrate sulfotransferase 14provided by HGNC
    Primary source
    HGNC:HGNC:24464
    See related
    Ensembl:ENSG00000169105 MIM:608429; AllianceGenome:HGNC:24464
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATCS; D4ST1; EDSMC1; HNK1ST
    Summary
    This gene encodes a member of the HNK-1 family of sulfotransferases. The encoded protein transfers sulfate to the C-4 hydroxyl of N-acetylgalactosamine residues in dermatan sulfate. Mutations in this gene have been associated with adducted thumb-clubfoot syndrome.[provided by RefSeq, Mar 2010]
    Orthologs
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    Genomic context

    See CHST14 in Genome Data Viewer
    Location:
    15q15.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (40470984..40473158)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (38278334..38280508)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (40763183..40765357)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40699201-40699700 Neighboring gene isovaleryl-CoA dehydrogenase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40728630-40729168 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40729169-40729706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40731858-40732395 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:40733201-40733702 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:40733703-40734202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40737995-40738496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9243 Neighboring gene bromo adjacent homology domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9244 Neighboring gene uncharacterized LOC124903473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40755909-40756410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40756411-40756910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9245 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6336 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40764047-40764950 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:40781343-40781994 Neighboring gene ribosomal protein L9 pseudogene 27 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6337 Neighboring gene Sharpr-MPRA regulatory region 12089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9246 Neighboring gene coiled-coil domain containing 32 Neighboring gene RNA, U6 small nuclear 516, pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 (CHST14) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables dermatan 4-sulfotransferase PubMed 
    enables dermatan 4-sulfotransferase  
    enables phosphate ion binding PubMed 
    enables protein binding PubMed 
    enables sulfotransferase activity  
    Component Evidence Code Pubs
    located_in Golgi membrane  
    located_in extracellular exosome PubMed 
    located_in membrane PubMed 

    General protein information

    Preferred Names
    carbohydrate sulfotransferase 14
    Names
    carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
    carbohydrate (dermatan 4) sulfotransferase 14
    dermatan 4 sulfotransferase 1
    NP_569735.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017074.1 RefSeqGene

      Range
      5001..7198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_600

    mRNA and Protein(s)

    1. NM_130468.4 → NP_569735.1  carbohydrate sulfotransferase 14

      See identical proteins and their annotated locations for NP_569735.1

      Status: REVIEWED

      Source sequence(s)
      AB066595, CR997569
      Consensus CDS
      CCDS10059.1
      UniProtKB/Swiss-Prot
      Q6PJ31, Q6UXA0, Q8NCH0, Q96P94
      UniProtKB/TrEMBL
      H0YN65
      Related
      ENSP00000307297.6, ENST00000306243.7
      Conserved Domains (1) summary
      pfam03567
      Location:144 → 364
      Sulfotransfer_2; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      40470984..40473158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      38278334..38280508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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