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    SMX3 mRNA splicing protein SMX3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856312, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SMX3
    Official Full Name
    mRNA splicing protein SMX3
    Primary source
    SGD:S000006386
    Locus tag
    YPR182W
    See related
    AllianceGenome:SGD:S000006386; FungiDB:YPR182W; VEuPathDB:YPR182W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables poly(U) RNA binding activity and splicing factor binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of spliceosomal snRNP complex. Orthologous to human SNRPF (small nuclear ribonucleoprotein polypeptide F). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SMX3 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (900194..900454)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene E1 ubiquitin-activating protein AOS1 Neighboring gene GTPase-activating protein SEC23 Neighboring gene dolichyl-phosphate beta-D-mannosyltransferase Neighboring gene bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Antibodies to yeast Sm motif 1 cross-react with human Sm core polypeptides. Bahia D, et al. Eur J Biochem, 1999 Apr. PMID 10215846
    2. Homomeric ring assemblies of eukaryotic Sm proteins have affinity for both RNA and DNA. Crystal structure of an oligomeric complex of yeast SmF. Collins BM, et al. J Biol Chem, 2003 May 9. PMID 12618433
    3. Functional characterization of nuclear localization signals in yeast Sm proteins. Bordonné R. Mol Cell Biol, 2000 Nov. PMID 11027265, Free PMC Article
    4. Stoichiometry of the Sm proteins in yeast spliceosomal snRNPs supports the heptamer ring model of the core domain. Walke S, et al. J Mol Biol, 2001 Apr 20. PMID 11302706
    5. Sm and Sm-like proteins belong to a large family: identification of proteins of the U6 as well as the U1, U2, U4 and U5 snRNPs. Séraphin B. EMBO J, 1995 May 1. PMID 7744014, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(U) RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables splicing factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal snRNP assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Sm-like protein family complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U5 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pICln-Sm protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mRNA splicing protein SMX3
    NP_015508.1
    • Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      900194..900454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184279.1 → NP_015508.1  TPA: mRNA splicing protein SMX3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015508.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4I2, P54999
      UniProtKB/TrEMBL
      A6ZX56, B3LKE1, C7GP64, C8ZJL1, G2WPZ3, N1NXW1
      Conserved Domains (1) summary
      cd01722
      Location:14 → 83
      Sm_F; Sm protein F
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54999.1

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