RTN4RL1 reticulon 4 receptor like 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RTN4RL1provided by HGNC
Official Full Name: reticulon 4 receptor like 1provided by HGNC
Primary source: HGNC:HGNC:21329
See related: Ensembl:ENSG00000185924 MIM:610461; AllianceGenome:HGNC:21329
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NgR3; NGRH2
Summary: Enables signaling receptor activity. Predicted to be involved in negative regulation of axon regeneration. Located in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in brain (RPKM 5.0), fat (RPKM 3.0) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17p13.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (1934677..2025334, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (1823462..1913269, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (1837971..1928628, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RTN4RL1 plays an important role in promoting the EMT of nasopharyngeal carcinoma (NPC) by regulating the phosphorylation of Src and FAK, thus activating their downstream pathways and eventually altering E-cadherin levels, F-actin polymerization, and cell polarity. Additionally, a high level of RTN4RL1 correlates with a poor prognosis of NPC.
Title: Overexpression of Nogo receptor 3 (NgR3) correlates with poor prognosis and contributes to the migration of epithelial cells of nasopharyngeal carcinoma patients.
Duplication of 10q22.3-q23.3 encompassing NGR3 gene is associated with congenital heart disease, microcephaly, and mild intellectual disability
Title: Duplication of 10q22.3-q23.3 encompassing BMPR1A and NGR3 associated with congenital heart disease, microcephaly, and mild intellectual disability.
Nogo receptor 3, a paralog of NgR1,functions as a NgR1 co-receptor for Nogo-66.
Title: Nogo receptor 3, a paralog of Nogo-66 receptor 1 (NgR1), may function as a NgR1 co-receptor for Nogo-66.
predominantly expressed in the neurons of the embryonic and adult nervous systems
Title: Two novel mammalian Nogo receptor homologs differentially expressed in the central and peripheral nervous systems.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G29262 (e-PCR)
- UniSTS:32074

STS-AA004275 (e-PCR)
- UniSTS:64075

D17S831 (e-PCR)
- UniSTS:34653

SHGC-148214 (e-PCR)
- UniSTS:176264

D17S654 (e-PCR), detects polymorphism
- UniSTS:43418

SHGC-149967 (e-PCR)
- UniSTS:177338

Rtn4rl1 (e-PCR), detects polymorphism
- UniSTS:547535

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chondroitin sulfate binding	ISS Inferred from Sequence or Structural Similarity more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axon regeneration	TAS Traceable Author Statement more info	PubMed
involved_in corpus callosum development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of axon regeneration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: reticulon-4 receptor-like 1

Names: Nogo-66 receptor homolog 2; Nogo-66 receptor-related protein 3; nogo receptor-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178568.4 → NP_848663.1 reticulon-4 receptor-like 1 precursor

See identical proteins and their annotated locations for NP_848663.1

Status: VALIDATED

Source sequence(s)

AC099684, AC130689

Consensus CDS

CCDS45569.1

UniProtKB/Swiss-Prot

A1A5E3, Q86UN2, Q8ND46

Related

ENSP00000330631.4, ENST00000331238.7

Conserved Domains (3) summary

sd00033
Location:57 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:174 → 233

LRR_8; Leucine rich repeat

cl15307
Location:255 → 300

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain