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    ETS2 ETS proto-oncogene 2, transcription factor [ Homo sapiens (human) ]

    Gene ID: 2114, updated on 10-Dec-2024

    Summary

    Official Symbol
    ETS2provided by HGNC
    Official Full Name
    ETS proto-oncogene 2, transcription factorprovided by HGNC
    Primary source
    HGNC:HGNC:3489
    See related
    Ensembl:ENSG00000157557 MIM:164740; AllianceGenome:HGNC:3489
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ETS2IT1
    Summary
    This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
    Expression
    Ubiquitous expression in spleen (RPKM 50.4), small intestine (RPKM 39.5) and 22 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ETS2 in Genome Data Viewer
    Location:
    21q22.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (38805183..38824955)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (37188973..37208712)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (40177107..40196879)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18458 Neighboring gene uncharacterized LOC107985480 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr21:40159061-40160260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:40176652-40177152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13312 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13315 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13316 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr21:40182837-40184036 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:40185951-40187150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:40194325-40194862 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr21:40203265-40204464 Neighboring gene uncharacterized LOC101928398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13317 Neighboring gene ETS2 antisense RNA 1 Neighboring gene ribosomal protein SA pseudogene 64

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (26 hits/1293 screens)

    EBI GWAS Catalog

    Description
    Genome-wide association study of chronic periodontitis in a general German population.
    EBI GWAS Catalog
    Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of v-ets erythroblastosis virus E26 oncogene homolog 2 (avian, ETS2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in chromatin  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    is_active_in nucleus  
    located_in plasma membrane  

    General protein information

    Preferred Names
    protein C-ets-2
    Names
    oncogene ETS-2
    v-ets avian erythroblastosis virus E2 oncogene homolog 2
    v-ets avian erythroblastosis virus E26 oncogene homolog 2
    v-ets erythroblastosis virus E26 oncogene homolog 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256295.2 → NP_001243224.1  protein C-ets-2 isoform 2

      See identical proteins and their annotated locations for NP_001243224.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and initiates translation at an alternate start codon, compared to variant 1. The resulting protein (isoform 2) has a longer N-terminus compared to isoform 1.
      Source sequence(s)
      AK000535, AK096841, AP001040, AP001041
      Conserved Domains (3) summary
      cd08543
      Location:225 → 313
      SAM_PNT-ETS-2; Sterile alpha motif (SAM)/Pointed domain of ETS-2
      smart00413
      Location:502 → 586
      ETS; erythroblast transformation specific domain
      pfam05350
      Location:39 → 143
      GSK-3_bind; Glycogen synthase kinase-3 binding
    2. NM_005239.6 → NP_005230.1  protein C-ets-2 isoform 1

      See identical proteins and their annotated locations for NP_005230.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform 1).
      Source sequence(s)
      AA452482, AK000535, BC042954, J04102
      Consensus CDS
      CCDS13659.1
      UniProtKB/Swiss-Prot
      A6NM68, D3DSH6, P15036, Q53Y89
      UniProtKB/TrEMBL
      A0A590UJP9
      Related
      ENSP00000354194.3, ENST00000360938.8
      Conserved Domains (2) summary
      cd08543
      Location:85 → 173
      SAM_PNT-ETS-2; Sterile alpha motif (SAM)/Pointed domain of ETS-2
      smart00413
      Location:362 → 446
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      38805183..38824955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005260935.2 → XP_005260992.1  protein C-ets-2 isoform X1

      See identical proteins and their annotated locations for XP_005260992.1

      UniProtKB/Swiss-Prot
      A6NM68, D3DSH6, P15036, Q53Y89
      UniProtKB/TrEMBL
      A0A590UJP9
      Conserved Domains (2) summary
      cd08543
      Location:85 → 173
      SAM_PNT-ETS-2; Sterile alpha motif (SAM)/Pointed domain of ETS-2
      smart00413
      Location:362 → 446
      ETS; erythroblast transformation specific domain
    2. XM_017028290.2 → XP_016883779.1  protein C-ets-2 isoform X1

      UniProtKB/Swiss-Prot
      A6NM68, D3DSH6, P15036, Q53Y89
      UniProtKB/TrEMBL
      A0A590UJP9
      Conserved Domains (2) summary
      cd08543
      Location:85 → 173
      SAM_PNT-ETS-2; Sterile alpha motif (SAM)/Pointed domain of ETS-2
      smart00413
      Location:362 → 446
      ETS; erythroblast transformation specific domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      37188973..37208712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324370.1 → XP_054180345.1  protein C-ets-2 isoform X1

      UniProtKB/Swiss-Prot
      A6NM68, D3DSH6, P15036, Q53Y89
      UniProtKB/TrEMBL
      A0A590UJP9
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