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    BIG1 Big1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856501, updated on 27-Dec-2024

    Summary

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    Official Symbol
    BIG1
    Official Full Name
    Big1p
    Primary source
    SGD:S000001143
    Locus tag
    YHR101C
    See related
    AllianceGenome:SGD:S000001143; FungiDB:YHR101C; VEuPathDB:YHR101C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in (1->6)-beta-D-glucan biosynthetic process. Acts upstream of or within vacuolar proton-transporting V-type ATPase complex assembly. Located in endoplasmic reticulum membrane. Used to study follicular lymphoma. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BIG1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    2
    Sequence:
    Chromosome: VIII; NC_001140.6 (314874..315968, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene histone acetyltransferase TRA1 Neighboring gene phosphatidylglycerophosphatase Neighboring gene putative serine/threonine protein kinase KIC1 Neighboring gene Sbe22p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deletion of the CaBIG1 gene reduces beta-1,6-glucan synthesis, filamentation, adhesion, and virulence in Candida albicans. Umeyama T, et al. Infect Immun, 2006 Apr. PMID 16552067, Free PMC Article
    2. Saccharomyces cerevisiae Big1p, a putative endoplasmic reticulum membrane protein required for normal levels of cell wall beta-1,6-glucan. Azuma M, et al. Yeast, 2002 Jun 30. PMID 12112232
    3. Rot1p of Saccharomyces cerevisiae is a putative membrane protein required for normal levels of the cell wall 1,6-beta-glucan. Machi K, et al. Microbiology (Reading), 2004 Oct. PMID 15470097
    4. ATP6AP1 deficiency causes an immunodeficiency with hepatopathy, cognitive impairment and abnormal protein glycosylation. Jansen EJ, et al. Nat Commun, 2016 May 27. PMID 27231034, Free PMC Article
    5. Big1 is a newly identified autophagy regulator that is critical for a fully functional V-ATPase. Lei Y, et al. Mol Biol Cell, 2024 Nov 1. PMID 39259764, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of BIG1 does not affect the rate of vegetative growth but does lead to defects in filamentation, adhesion, and virulence in the kidneys of infected mice.
      Title: Deletion of the CaBIG1 gene reduces beta-1,6-glucan synthesis, filamentation, adhesion, and virulence in Candida albicans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in (1->6)-beta-D-glucan biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in (1->6)-beta-D-glucan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vacuolar proton-transporting V-type ATPase complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within vacuolar proton-transporting V-type ATPase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vacuolar proton-transporting V-type ATPase complex assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Big1p
    NP_011969.1
    • Integral ER membrane protein; involved in the assembly and function of the V-ATPase; proposed role as a signaling component that regulates autophagy independent of TOR; required for biosynthesis of cell wall beta-1,6-glucan; functional homolog of human ATP6AP1; analogous follicular lymphoma-associated mutation induces autophagy

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      314874..315968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179231.1 → NP_011969.1  TPA: Big1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011969.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL51, P38813
      UniProtKB/TrEMBL
      A6ZT09, B3LSL6, C8Z9P4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38813.1

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