SPO22 Spo22p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SPO22
Official Full Name: Spo22p
Primary source: SGD:S000001335
Locus tag: YIL073C
See related: AllianceGenome:SGD:S000001335; FungiDB:YIL073C; VEuPathDB:YIL073C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ZIP4
Summary: Involved in positive regulation of protein sumoylation and regulation of synaptonemal complex assembly. Located in nucleus. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 2. Orthologous to human TEX11 (testis expressed 11). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SPO22 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 2

Sequence:: Chromosome: IX; NC_001141.2 (222937..225954, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ur data support a model in which the Zip2:Zip4:Spo16 complex binds and stabilizes early meiotic recombination intermediates, then coordinates additional factors to promote crossover formation and license downstream events including synaptonemal complex assembly.
Title: The conserved XPF:ERCC1-like Zip2:Spo16 complex controls meiotic crossover formation through structure-specific DNA binding.
Identification of the ZZS (Zip2-Zip4-Spo16) complex which is required for crossover formation.
Title: A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation.
ZIP4 was not required for centromere pairing during pachytene, but was required for proper segregation of achiasmate chromosomes.
Title: Meiotic Centromere Coupling and Pairing Function by Two Separate Mechanisms in Saccharomyces cerevisiae.
The excess crossovers observed in synaptonemal complex (SC), central element-deficient mutants are Msh4, Zip1, and Zip4 dependent, clearly indicating the existence of two classes of SC proteins-a class with procrossover function(s) that are also necessary for SC assembly and a class that is not required for crossover formation but essential for SC assembly
Title: Synaptonemal Complex Proteins of Budding Yeast Define Reciprocal Roles in MutSγ-Mediated Crossover Formation.
Interference and assurance in genetic crossovers are mechanistically distinct processes that are separated by mutations in a new ZMM protein from Saccharomyces cerevisiae, Spo16.
Title: Crossover assurance and crossover interference are distinctly regulated by the ZMM proteins during yeast meiosis.
Spo22 (also called Zip4) is identified as a probable functional collaborator of Zip2/3
Title: Bioinformatic analyses implicate the collaborating meiotic crossover/chiasma proteins Zip2, Zip3, and Spo22/Zip4 in ubiquitin labeling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein sumoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptonemal complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptonemal complex assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptonemal complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sporulation resulting in formation of a cellular spore	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: Spo22p

NP_012192.2

Meiosis-specific protein essential for chromosome synapsis; involved in completion of nuclear divisions during meiosis; induced early in meiosis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

222937..225954 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179423.1 → NP_012192.2 TPA: Spo22p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012192.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVL1, P40511

UniProtKB/TrEMBL

C8ZAH2, N1P0Z1

Conserved Domains (1) summary

pfam08631
Location:194 → 476

SPO22; Meiosis protein SPO22/ZIP4 like