PEP5 tethering complex subunit PEP5 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: PEP5
Official Full Name: tethering complex subunit PEP5
Primary source: SGD:S000004844
Locus tag: YMR231W
See related: AllianceGenome:SGD:S000004844; FungiDB:YMR231W; VEuPathDB:YMR231W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: END1; VAM1; VPL9; VPS11; VPT11
Summary: Enables ubiquitin protein ligase activity. Contributes to phosphatidylinositol binding activity. Involved in several processes, including Golgi to endosome transport; histone catabolic process; and vacuole fusion, non-autophagic. Located in fungal-type vacuole membrane. Part of CORVET complex and HOPS complex. Used to study Parkinson's disease and hypomyelinating leukodystrophy 12. Human ortholog(s) of this gene implicated in dystonia 32 and hypomyelinating leukodystrophy 12. Orthologous to human VPS11 (VPS11 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
contributes_to phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to endosome transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in histone catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in late endosome to vacuole transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in organelle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of SNARE complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in vacuole fusion, non-autophagic	IDA Inferred from Direct Assay more info	PubMed
involved_in vacuole fusion, non-autophagic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuole organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle docking involved in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle tethering	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CORVET complex	IDA Inferred from Direct Assay more info	PubMed
part_of HOPS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of HOPS complex	IPI Inferred from Physical Interaction more info	PubMed
located_in bounding membrane of organelle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info
part_of vesicle tethering complex	IEA Inferred from Electronic Annotation more info

NP_013958.1

Histone E3 ligase, component of CORVET membrane tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p; involved in ubiquitination and degradation of excess histones

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