Gtsf1 gametocyte specific factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gtsf1provided by MGI
Official Full Name: gametocyte specific factor 1provided by MGI
Primary source: MGI:MGI:1921424
See related: Ensembl:ENSMUSG00000022487 AllianceGenome:MGI:1921424
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cue110; 1700006H03Rik
Summary: Predicted to enable tRNA binding activity. Involved in piRNA-mediated gene silencing by mRNA destabilization and secondary piRNA processing. Located in cytoplasm. Is active in piP-body. Is expressed in gonad. Orthologous to human GTSF1 (gametocyte specific factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis adult (RPKM 121.4) See more
Orthologs: human all
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Genomic context

Location:: 15 F3; 15 58.93 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (103310885..103338872, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (103402458..103430445, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins.
Title: GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins.
Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons.
Title: Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons.
Our findings indicate that GTSF1 is a crucial factor for the slicing of target RNAs by PIWI-piRNAs and thus affects secondary piRNA biogenesis in prospermatogonia.
Title: Mouse GTSF1 is an essential factor for secondary piRNA biogenesis.
Results indicate that Gtsf1/Cue110 is required for spermatogenesis and involved in retrotransposon suppression in male germ cells.
Title: Gtsf1/Cue110, a gene encoding a protein with two copies of a CHHC Zn-finger motif, is involved in spermatogenesis and retrotransposon suppression in murine testes.
Expression pattern of Gtsf1 and its high conservation suggests that it may play an important role in germ cell development.
Title: Expression and localization of the novel and highly conserved gametocyte-specific factor 1 during oogenesis and spermatogenesis.
the Cue110 gene is expressed predominantly in male germ cells at stages from the pachytene spermatocytes to round spermatids
Title: Gene expression pattern of Cue110: a member of the uncharacterized UPF0224 gene family preferentially expressed in germ cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (1) 1 citation

General gene information

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Markers

Gtsf1 (e-PCR), detects polymorphism
- UniSTS:507968

Gtsf1 (e-PCR), detects polymorphism
- UniSTS:525736

Gtsf1 (e-PCR), detects polymorphism
- UniSTS:525737

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in piRNA-mediated gene silencing by mRNA destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in secondary piRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in piP-body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: gametocyte-specific factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.