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    Atp5mc1 ATP synthase membrane subunit c locus 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29754, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atp5mc1provided by RGD
    Official Full Name
    ATP synthase membrane subunit c locus 1provided by RGD
    Primary source
    RGD:61933
    See related
    EnsemblRapid:ENSRNOG00000007235 AllianceGenome:RGD:61933
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Atp5g1
    Summary
    Enables ligand-gated channel activity. Involved in several processes, including cellular response to L-glutamate; cold acclimation; and negative regulation of mitochondrial membrane potential. Located in distal axon and neuronal cell body. Part of proton-transporting ATP synthase complex, coupling factor F(o). Orthologous to human ATP5MC1 (ATP synthase membrane subunit c locus 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 4869.4), Muscle (RPKM 2859.4) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp5mc1 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (81520762..81523735, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (81024056..81026780, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (83895941..83898640, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene high mobility group protein B1-like Neighboring gene SNF8 subunit of ESCRT-II Neighboring gene ubiquitin-conjugating enzyme E2Z Neighboring gene calcium binding and coiled-coil domain 2 Neighboring gene tubulin tyrosine ligase like 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inhibition of Bcl-xL prevents pro-death actions of ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity. Park HA, et al. Cell Death Differ, 2017 Nov. PMID 28777375, Free PMC Article
    2. Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition. Bonora M, et al. Cell Cycle, 2013 Feb 15. PMID 23343770, Free PMC Article
    3. Local translation of ATP synthase subunit 9 mRNA alters ATP levels and the production of ROS in the axon. Natera-Naranjo O, et al. Mol Cell Neurosci, 2012 Mar. PMID 22209705
    4. MicroRNA-338 regulates the axonal expression of multiple nuclear-encoded mitochondrial mRNAs encoding subunits of the oxidative phosphorylation machinery. Aschrafi A, et al. Cell Mol Life Sci, 2012 Dec. PMID 22773120, Free PMC Article
    5. Batten disease and the control of the Fo subunit c pore by cGMP and calcium. McGeoch JE, et al. Eur J Paediatr Neurol, 2001. PMID 11588987

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that microRNA-338 (miR-338) modulation of local cytochrome c oxidase IV (COXIV) and ATP synthase subunit 9 (ATP5G1) expression has a marked effect on axonal reactive oxygen species levels, as well as axonal growth.
      Title: MicroRNA-338 regulates the axonal expression of multiple nuclear-encoded mitochondrial mRNAs encoding subunits of the oxidative phosphorylation machinery.
    2. The c subunit of the F0 ATP synthase constitutes a critical component of the mitochondrial permeability transition pore.
      Title: Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition.
    3. The siRNA-mediated knock-down of axonal ATP5G1 mRNA resulted in a significant reduction of axonal ATP5G1 protein and ATP levels. Silencing of local ATP5G1 expression enhanced the production of local reactive oxygen species.
      Title: Local translation of ATP synthase subunit 9 mRNA alters ATP levels and the production of ROS in the axon.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ligand-gated channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to L-glutamate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cold acclimation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of mitochondrial membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of reactive oxygen species biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pore complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to 3,3',5-triiodo-L-thyronine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cation channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in distal axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proton-transporting ATP synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP synthase F(0) complex subunit C1, mitochondrial
    Names
    ATP synthase H+ transporting mitochondrial F0 complex subunit c (subunit 9)
    ATP synthase lipid-binding protein, mitochondrial
    ATP synthase proteolipid P1
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9)
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9)
    ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
    ATPase protein 9
    ATPase subunit c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017311.1 → NP_059007.1  ATP synthase F(0) complex subunit C1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_059007.1

      Status: PROVISIONAL

      Source sequence(s)
      D13123
      UniProtKB/Swiss-Prot
      Q06645
      UniProtKB/TrEMBL
      A6HID1
      Related
      ENSRNOP00000108669.1, ENSRNOT00000009815.7
      Conserved Domains (1) summary
      MTH00222
      Location:62 → 136
      ATP9; ATP synthase F0 subunit 9; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      81520762..81523735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247188.5 → XP_006247250.1  ATP synthase F(0) complex subunit C1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006247250.1

      UniProtKB/Swiss-Prot
      Q06645
      UniProtKB/TrEMBL
      A6HID1
      Conserved Domains (1) summary
      MTH00222
      Location:62 → 136
      ATP9; ATP synthase F0 subunit 9; Provisional

    2. XM_006247189.3 → XP_006247251.1  ATP synthase F(0) complex subunit C1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006247251.1

      UniProtKB/Swiss-Prot
      Q06645
      UniProtKB/TrEMBL
      A6HID1
      Conserved Domains (1) summary
      MTH00222
      Location:62 → 136
      ATP9; ATP synthase F0 subunit 9; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06645.1 GenPept UniProtKB/Swiss-Prot:Q06645

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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