Pnp purine nucleoside phosphorylase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pnpprovided by RGD
Official Full Name: purine nucleoside phosphorylaseprovided by RGD
Primary source: RGD:1597189
See related: EnsemblRapid:ENSRNOG00000009982 AllianceGenome:RGD:1597189
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Np
Summary: Enables purine-nucleoside phosphorylase activity. Predicted to be involved in several processes, including nucleoside catabolic process; nucleotide metabolic process; and positive regulation of interleukin-2 production. Predicted to act upstream of or within inosine catabolic process; positive regulation of T cell activation; and urate biosynthetic process. Located in extracellular region. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 1207.2), Lung (RPKM 1012.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p14

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (26644147..26651808)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (24170607..24178269)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (27875883..27883566)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Purine nucleoside phosphorylase inhibition ameliorates age-associated lower urinary tract dysfunctions.
Title: Purine nucleoside phosphorylase inhibition ameliorates age-associated lower urinary tract dysfunctions.
A preliminary kinetic characterization is performed for purine nucleoside phosphorylase found in rat cerebrospinal fluid.
Title: Purine nucleoside phosphorylase activity in rat cerebrospinal fluid.

Submit: New GeneRIF Correction

General gene information

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Markers

RH125524 (e-PCR)
- UniSTS:162340

RH140701 (e-PCR)
- UniSTS:222768

RH127813 (e-PCR)
- UniSTS:211123

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanosine phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nucleoside binding	ISO Inferred from Sequence Orthology more info
enables phosphate ion binding	ISO Inferred from Sequence Orthology more info
enables purine nucleobase binding	ISO Inferred from Sequence Orthology more info
enables purine-nucleoside phosphorylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables purine-nucleoside phosphorylase activity	IDA Inferred from Direct Assay more info	PubMed
enables purine-nucleoside phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables purine-nucleoside phosphorylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in IMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in allantoin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in dAMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in deoxyadenosine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in deoxyinosine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inosine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in inosine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in nicotinamide riboside catabolic process	ISO Inferred from Sequence Orthology more info
involved_in nucleobase-containing compound metabolic process	ISO Inferred from Sequence Orthology more info
involved_in nucleotide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of alpha-beta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in purine ribonucleoside salvage	IEA Inferred from Electronic Annotation more info
involved_in purine-containing compound salvage	ISO Inferred from Sequence Orthology more info
involved_in purine-containing compound salvage	TAS Traceable Author Statement more info	PubMed
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within urate biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: purine nucleoside phosphorylase

Names: inosine phosphorylase; inosine-guanosine phosphorylase; nucleoside phosphorylase

NP_001386607.1

EC 2.4.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399678.1 → NP_001386607.1 purine nucleoside phosphorylase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

A6KEC5, P85973

Related

ENSRNOP00000108358.1, ENSRNOT00000162602.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

26644147..26651808

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001106031.1: Suppressed sequence

Description

NM_001106031.1: This RefSeq was removed because currently there is insufficient support for the transcript.