Cxxc4 CXXC finger protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cxxc4provided by RGD
Official Full Name: CXXC finger protein 4provided by RGD
Primary source: RGD:69228
See related: AllianceGenome:RGD:69228
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Idax
Summary: Enables PDZ domain binding activity. Predicted to be involved in negative regulation of Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway. Predicted to be located in cytoplasmic vesicle and nucleus. Orthologous to human CXXC4 (CXXC finger protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 33.3), Heart (RPKM 28.9) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q43

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (225329044..225363347)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (222664148..222689365)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (239414882..239439640)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CXXC4 mediates glucose-induced beta-cell proliferation.
Title: CXXC4 mediates glucose-induced β-cell proliferation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140132 (e-PCR)
- UniSTS:222211

RH134190 (e-PCR)
- UniSTS:217472

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables methyl-CpG binding	IBA Inferred from Biological aspect of Ancestor more info
enables methyl-CpG binding	ISO Inferred from Sequence Orthology more info
enables methyl-CpG binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CXXC-type zinc finger protein 4

Names: CXXC finger 4; Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex); inhibition of the Dvl and axin complex protein; inhibitor of the Dvl and Axin complex

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053342.4 → NP_445794.4 CXXC-type zinc finger protein 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

M0RDW5

Conserved Domains (1) summary

pfam02008
Location:299 → 339

zf-CXXC; CXXC zinc finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

225329044..225363347

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233339.5 → XP_006233401.2 CXXC-type zinc finger protein 4 isoform X1

Conserved Domains (1) summary

pfam02008
Location:299 → 339

zf-CXXC; CXXC zinc finger domain
XM_006233341.5 → XP_006233403.2 CXXC-type zinc finger protein 4 isoform X1

Conserved Domains (1) summary

pfam02008
Location:299 → 339

zf-CXXC; CXXC zinc finger domain