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    Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294103, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Papss2provided by RGD
    Official Full Name
    3'-phosphoadenosine 5'-phosphosulfate synthase 2provided by RGD
    Primary source
    RGD:1307012
    See related
    EnsemblRapid:ENSRNOG00000011068 AllianceGenome:RGD:1307012
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable adenylylsulfate kinase activity and sulfate adenylyltransferase (ATP) activity. Predicted to be involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process; hormone metabolic process; and sulfate assimilation. Predicted to act upstream of or within blood coagulation and bone development. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Pakistani type. Orthologous to human PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 267.4), Kidney (RPKM 113.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Papss2 in Genome Data Viewer
    Location:
    1q52
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (239867597..239952614)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (230454314..230539332)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (251145264..251230716)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene multiple inositol-polyphosphate phosphatase 1 Neighboring gene uncharacterized LOC134485221 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134485222 Neighboring gene ATPase family, AAA domain containing 1 Neighboring gene glutathione S-transferase P 1-like Neighboring gene phosphatase and tensin homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genomic organization of the mouse and human genes encoding the ATP sulfurylase/adenosine 5'-phosphosulfate kinase isoform SK2. Kurima K, et al. J Biol Chem, 1999 Nov 19. PMID 10559207
    2. The growth of femur and tibia in three genetically distinct chondrodystrophic mutants of the house mouse. Johnson DR. J Anat, 1978 Feb. PMID 624676, Free PMC Article
    3. Molecular markers near the mouse brachymorphic (bm) gene, which affects connective tissues and bleeding time. Rusiniak ME, et al. Mamm Genome, 1996 Feb. PMID 8835524
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189455

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylylsulfate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylylsulfate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables selenate adenylyltransferase (ATP) activity TAS
    Traceable Author Statement
    more info
    		  
    enables sulfate adenylyltransferase (ATP) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within bone development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfate assimilation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate assimilation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sulfate assimilation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfate assimilation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
    NP_001099845.2
    XP_006231336.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106375.2 → NP_001099845.2  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

      See identical proteins and their annotated locations for NP_001099845.2

      Status: PROVISIONAL

      Source sequence(s)
      BC169061
      UniProtKB/TrEMBL
      B5DFH4
      Related
      ENSRNOP00000074860.2, ENSRNOT00000083555.3
      Conserved Domains (3) summary
      cd00517
      Location:243 → 606
      ATPS; ATP-sulfurylase
      cd02027
      Location:43 → 193
      APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...
      TIGR00339
      Location:225 → 605
      sopT; ATP sulphurylase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      239867597..239952614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231274.5 → XP_006231336.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K950
      Related
      ENSRNOP00000014979.5, ENSRNOT00000014979.7
      Conserved Domains (3) summary
      cd00517
      Location:243 → 611
      ATPS; ATP-sulfurylase
      cd02027
      Location:43 → 193
      APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...
      TIGR00339
      Location:225 → 610
      sopT; ATP sulphurylase
    Nucleotide Protein Strain
    Heading Accession and Version

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