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    TRS33 Trs33p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854282, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TRS33
    Official Full Name
    Trs33p
    Primary source
    SGD:S000005641
    Locus tag
    YOR115C
    See related
    AllianceGenome:SGD:S000005641; FungiDB:YOR115C; VEuPathDB:YOR115C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of macroautophagy; and protein localization to phagophore assembly site. Located in cis-Golgi network; phagophore assembly site; and trans-Golgi network. Part of TRAPPI protein complex; TRAPPII protein complex; and TRAPPIII protein complex. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy. Orthologous to several human genes including TRAPPC6B (trafficking protein particle complex subunit 6B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TRS33 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (538659..539465, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Azf1p Neighboring gene mitochondrial HMG-box protein CIM1 Neighboring gene DNA-directed RNA polymerase III core subunit RPO31 Neighboring gene proteasome regulatory particle base subunit RPT5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TRAPP stimulates guanine nucleotide exchange on Ypt1p. Wang W, et al. J Cell Biol, 2000 Oct 16. PMID 11038176, Free PMC Article
    2. Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p. Kim MS, et al. Traffic, 2005 Dec. PMID 16262728
    3. Sequential interactions with Sec23 control the direction of vesicle traffic. Lord C, et al. Nature, 2011 May 12. PMID 21532587, Free PMC Article
    4. Trs33-Containing TRAPP IV: A Novel Autophagy-Specific Ypt1 GEF. Lipatova Z, et al. Genetics, 2016 Nov. PMID 27672095, Free PMC Article
    5. The role of Trs65 in the Ypt/Rab guanine nucleotide exchange factor function of the TRAPP II complex. Liang Y, et al. Mol Biol Cell, 2007 Jul. PMID 17475775, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. One of the roles of Trs33p is to facilitate the incorporation of the Bet3p subunit into assembling transport protein particle complexes.
      Title: Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of macroautophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to phagophore assembly site IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein-containing complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein-containing complex localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TRAPP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPPI protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TRAPPII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TRAPPIII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cis-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagophore assembly site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagophore assembly site IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in phagophore assembly site IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Trs33p
    NP_014758.3
    • Core component of TRAPP complexes I, II and IV; transport protein particle (TRAPP) complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII, and IV); proposed subunit of a novel complex, TRAPPIV, that may function redundantly with TRAPPIII as a GEF that activates Ypt1 during autophagy

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      538659..539465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183534.3 → NP_014758.3  TPA: Trs33p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014758.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2H4, Q99394
      UniProtKB/TrEMBL
      A6ZNW3, B3LJF8, B5VS06, C7GMM1, C8ZI77, G2WMZ1, N1NWY8
      Conserved Domains (1) summary
      cd14944
      Location:41 → 265
      TRAPPC6A_Trs33; Trs33 subunit of the TRAPP complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99394.1

    Gene LinkOut

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