Prorp protein only RNase P catalytic subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prorpprovided by MGI
Official Full Name: protein only RNase P catalytic subunitprovided by MGI
Primary source: MGI:MGI:1913382
See related: Ensembl:ENSMUSG00000021023 AllianceGenome:MGI:1913382
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mrpp3; mKIAA0391; 1110008L16Rik
Summary: Predicted to enable ribonuclease P activity. Predicted to be involved in mitochondrial tRNA 5'-end processing and tRNA 5'-leader removal. Located in mitochondrial nucleoid. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 54. Orthologous to human PRORP (protein only RNase P catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 2.8), bladder adult (RPKM 2.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C1; 12 23.91 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (55349422..55429276)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (55302637..55382492)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ribonuclease P activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonuclease P activity	ISO Inferred from Sequence Orthology more info
enables ribonuclease P activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mitochondrial tRNA 5'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial tRNA 5'-end processing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial tRNA 5'-end processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA 5'-leader removal	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrial nucleoid	IDA Inferred from Direct Assay more info	PubMed
part_of mitochondrial ribonuclease P complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial ribonuclease P complex	ISO Inferred from Sequence Orthology more info
part_of mitochondrial ribonuclease P complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial ribonuclease P catalytic subunit

Names: mitochondrial RNase P protein 3; mitochondrial ribonuclease P protein 3

NP_079649.1

EC 3.1.26.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.